Distributions of Taurine, Glutamate, and Glutamate Receptors during Post-Natal Development and Plasticity in the Rat Brain
Part of the
Advances in Experimental Medicine and Biology
book series (AEMB, volume 403)
Taurine and glutamate both play roles in the development of the mammalian nervous system10, 17, 46. Taurine is involved in granule cell migration in the developing cerebellum37, 47, 48, 50 and is in high concentrations within axons of the optic tract before and during the establishment and refinement of synapses12, 34, 45. Glutamate, and one subtype of glutamate receptor, the N-methyl-D-aspartate (NMDA) receptor, have also been shown to be involved in the process of granule cell migration in the cerebellum10. NMDA receptors also appear to influence neurite outgrowth and survival of these granule cells2, 32, 35. In the hippocampus, glutamate promotes branching of neurites and synapse formation3, 26, 28. These studies indicate that there is an optimal range of glutamate concentration during development that promotes complexity, but higher concentrations are lethal to the developing neuron26. An inhibitory transmitter, γ-aminobutyric acid (GABA), is able to reduce the glutamate-in-duced regression of dendrites in culture25, suggesting that a modulatory influence is necessary during development to encourage optimal growth, while preventing excitotoxicity.
KeywordsPurkinje Cell Glutamate Receptor Granule Cell Dentate Gyrus Entorhinal Cortex
Altman, J. 1972, Postnatal development of the cerebellar cortex in the rat. II. Phases in the maturation of Purkinje cells and of the molecular layer, J. Comp. Neurol.
Balazs, R., Jorgensen, O.S. and Hack, N. 1988, Stimulation of the N-methyl-D-aspartate receptor has a trophic effect on differentiating cerebellar granule cells, Neuroscience
, 27:437–451.CrossRefGoogle Scholar
Brewer, G.J. and Cotman, C.W. 1989, NMDA receptor regulation of neuronal morphology in cultured hippocampal neurons, Neurosci. Lett.
, 99:268–273.CrossRefGoogle Scholar
Choi, D.W. 1987, Ionic dependence of glutamate neurotoxicity, J. Neurosci.
Collins, R.C. 1986, Selective vulnerability of brain: New insights from the excitatory synapse, Metab. Brain Dis.
Cotman, C.W., Matthews, D.A., Taylor, D. and Lynch, G. 1973, Synaptic rearrangement in the dentate gyrus: Histochemical evidence of adjustments after lesions in immature and adult rats, Proc. Natl. Acad. Sci. USA
, 70:3473–3477.CrossRefGoogle Scholar
Dure, L.S., Young, A.B. and Penney, J.B. 1991, Excitatory amino acid binding sites in the caudate nucleus and frontal cortex of Huntington’s disease, Ann. Neurol.
, 30:785–793.CrossRefGoogle Scholar
French, E.D., Vezzani, A., Whetsell Jr., W.O. and Schwarcz. R. 1986, Antiexcitotoxic actions of taurine in the rat hippocampus studied in vivo and in vitro, Adv. Exp. Med. Biol.
Grandes, P. and Streit, P. 1991, Effect of perforant path lesion on pattern of glutamate-like immunoreactivity in rat dentate gyrus, Neuroscience
, 41:390–400.CrossRefGoogle Scholar
Komuro, H. and Rakic, P. 1993, Modulation of neuronal migration by NMDA receptors, Science
, 260:95–97.CrossRefGoogle Scholar
Kontro, P. and Oja, S.S. 1989, Release of taurine and GABA from cerebellar slices from developing and adult mice, Neuroscience
, 29:413–423.CrossRefGoogle Scholar
Lake, N. 1992, Taurine, GABA and GFAP immunoreactivity in the developing and adult rat optic nerve, Brain Res.
, 596:124–132.CrossRefGoogle Scholar
Lehmann, A., Hagberg, H. and Hamberger, A. 1984, A role for taurine in the maintenance of homeostasis in the central nervous system during hyperexcitation, Neurosci.Lett
, 52:341–346.CrossRefGoogle Scholar
Lehmann, A., Hagberg, H., Lazarewicz, J.W., Jacobson, I. and Hamberger, A. 1986, Alterations in extracellular amino acids and Ca2+
following excitotoxin administration and during status epilepticus, Adv. Exp. Med. Biol.
, 203:363–373.CrossRefGoogle Scholar
Lehmann, A., Isacsson, H. and Hamberger, A. 1983, Effects of in vivo administration of kainic acid on the extracellular amino acid pool in the rabbit hippocampus, J. Neurochem.
Lehmann, A., Lazarewicz, J.W. and Zeise, M. 1985, N-Methylaspartate-evoked liberation of taurine and phosphonoethanolamine in vivo: Site of release, J. Neurochem.
, 45:1172–1177.CrossRefGoogle Scholar
Lipton, S.A. and Kater, S.B. 1989, Neurotransmitter regulation of neuronal outgrowth, plasticity and survival, Trends Neurosci.
Lu, P., Schuller-Levis, G. and Sturman, J.A. 1991, Distribution of taurine-like immunoreactivity in cerebellum of kittens from taurine-supplemented and taurine-deficient mothers, Int. J. Dev. Neurosci.
Lynch, G., Deadwyler, S. and Cotman, C. 1973, Postlesion axonal growth produces permanent functional connections, Science
Magnusson, K.R., Clements, J.R., Wu, J.-Y. and Beitz, A.J. 1989, Colocalization of taurine-and cysteine sulfinic acid decarboxylase-like immunoreactivity in the hippocampus of the rat, Synapse
, 4:55–69.CrossRefGoogle Scholar
Magnusson, K.R. and Cotman, C.W. 1993, Age-related changes in excitatory amino acid receptors in two mouse strains, Neurobiol. Aging
, 14:197–206.CrossRefGoogle Scholar
Magnusson, K.R., Koerner, J.F., Larson, A.A., Smullin, D.H., Skilling, S.R. and Beitz, A.J. 1991, NMDA-, kainate-and quisqualate-stimulated release of taurine from electrophysiologically-monitored rat hippocampal slices, Brain Res.
, 549:1–8.CrossRefGoogle Scholar
Magnusson, K.R., Madl, J.E., Clements, J.R., Wu, J., Larson, A.A. and Beitz, A.J. 1988, Colocalization of taurine-and cysteine sulfinic acid decarboxylase-like immunoreactivity in the cerebellum of the rat with monoclonal antibodies against taurine, J. Neurosci.
, 8:4551–4564.Google Scholar
Matthews, D.A., Cotman, C. and Lynch, G. 1976, An electron microscopic study of lesion-induced synaptogenesis in the dentate gyrus of the adult rat. I. Magnitude and time course of degeneration, Brain Res.
Mattson, M.P. and Kater, S.B. 1989, Excitatory and inhibitory neurotransmitters in the generation and degeneration of hippocampal neuroarchitecture, Brain Res.
, 478:337–348.CrossRefGoogle Scholar
Mattson, M.P., Lee, R.E., Adams, M.E., Guthrie, PB. and Kater, S.B. 1988, Interactions between entorhinal axons and target hippocampal neurons: A role for glutamate in the development of hippocampal circuitry, Neuron
, 1:865–876.CrossRefGoogle Scholar
McDonald, A.J., Beitz, A.J., Larson, A.A., Kuriyama, R., Sellitto, C. and Madl, J.E. 1989, Colocalization of glutamate and tubulin in putative excitatory neurons of the hippocampus and amygdala: An immunohistochemical study using monoclonal antibodies, Neuroscience
, 30:405–421.CrossRefGoogle Scholar
McDonald, J.W. and Johnston, M.V., 1990, Physiological and pathophysiological roles of excitatory amino acids during central nervous system development, Brain Res. Rev.
15: 41–70.CrossRefGoogle Scholar
McDonald, J.W., Silverstein, F.S. and Johnston, M.V. 1988, Neurotoxicity of N-methyl-D-aspartate is markedly enhanced in developing rat central nervous system, Brain Res.
, 459:200–203.CrossRefGoogle Scholar
Naik, N.T. 1963, Technical variations in Koelle’s histochemical method for demonstrating cholinesterase activity, Quart. J. Microsc. Sci.
Oja, S.S. and Kontro, P. 1983, Free amino acids in epilepsy: Possible role of taurine, Acta Neurol. Scand.
, 67(Suppl. 93):5–20.Google Scholar
Pearce, I.A., Cambray-Deakin, M.A. and Burgoyne, R.D. 1987, Glutamate acting on NMDA receptors stimulates neurite outgrowth from cerebellar granule cells, FEBS Lett.
, 223:143–147.CrossRefGoogle Scholar
Pokorny, J. and Yamamoto, T. 1981, Postnatal ontogenesis of hippocampal CA1 area in rats. I. Development of dendritic arborisation in pyramidal neurons, Brain Res. Bull.
, 7:113–120.CrossRefGoogle Scholar
Politis, M.J. and Ingoglia, N.A. 1979, Axonal transport of taurine along neonatal and young adult rat optic axons, Brain Res.
Rashid, N.A. and Cambray-Deakin, M.A. 1992, N-methyl-D-aspartate effects on the growth, morphology, and cytoskeleton of individual neurons in vitro, Dev. Brain Res.
, 67:301–308.CrossRefGoogle Scholar
Rassin, D.K. 1982, Taurine, cysteinesulfinic acid decarboxylase and glutamic acid in brain, Adv. Exp. Med.Biol.
Roffler-Tarlov, S. and Turey, M. 1982, The content of amino acids in the developing cerebellar cortex and deep cerebellar nuclei of granule cell deficient mutant mice, Brain Res.
, 247:65–73.CrossRefGoogle Scholar
Saransaari, P. and Oja, S.S. 1991, Excitatory amino acids evoke taurine release from cerebral cortex slices from adult and developing mice, Neuroscience
, 45:451–459.CrossRefGoogle Scholar
Scheff, S.W., Benardo, L.S. and Cotman, C.W. 1980, Decline in reactive fiber growth in the dentate gyrus of aged rats compared to young adult rats following entorhinal cortex removal, Brain Res.
Schurr, A., Tseng, M.T., West, C.A. and Rigor, B.M. 1987, Taurine improves the recovery of neuronal function following cerebral hypoxia: An in vitro study, Life Sci.
, 40:2059–2066.CrossRefGoogle Scholar
Silverstein, F.S., Chen, R.C. and Johnston, M.V. 1986, The glutamate agonist quisqualic acid is neurotoxic in striatum and hippocampus, Neurosci. Lett.
, 71:13–18.CrossRefGoogle Scholar
Stanfield, B.B. and Cowan, W.M. 1982, The sprouting of septal afferents to the dentate gyrus after lesions of the entorhinal cortex in adult rats, Brain Res.
, 232:162–170.CrossRefGoogle Scholar
Steward, O. 1977, Topographic organization of the projections from the entorhinal area to the hippocam-pal formation of the rat, J. Comp. Neurol.
Steward, O. and Vinsant, S.L. 1983, The process of reinnervation in the dentate gyrus of the adult rat: A quantitative electron microscopic analysis of terminal proliferation and reactive synaptogenesis, J. Comp. Neurol.
, 214:370–386.CrossRefGoogle Scholar
Sturman, J.A. 1979, Taurine in the developing rabbit visual system: Changes in concentration and axonal transport including a comparison with axonally transported proteins, J. Neurobiol.
Sturman, J.A. 1993, Taurine in development, Physiol. Rev.
, 73:119–147.Google Scholar
Sturman, J.A., Moretz, R.C., French, J.H. and Wisniewski, H.M. 1985, Postnatal taurine deficiency in the kitten results in a persistence of the cerebellar external granule cell layer: Correction by taurine feeding, J. Neurosci. Res.
Sturman, J.A., Moretz, R.C., French, J.H. and Wisniewski, H.M. 1985, Taurine deficiency in the developing cat: Persistence of the cerebellar external granule cell layer, J. Neurosci. Res.
Toth, E., Lathja, A., Sarhan, S. and Seiler, N. 1983, Anticonvulsant effects of some inhibitory neurotransmitter amino acids, Neurochem. Res.
, 8:291–302.CrossRefGoogle Scholar
Trenkner, E. 1990, The role of taurine and glutamate during early postnatal cerebellar development of normal and weaver mutant mice, Adv. Exp. Med. Biol.
, 268:239–244.Google Scholar
Trenkner, E., Gargano, A., Scala, P. and Sturman, J. 1992, Taurine synthesis in cat and mouse in vivo and in vitro, Adv. Exp. Med. Biol.
, 315:7–14.CrossRefGoogle Scholar
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