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In Vivo Release of Taurine from Rat Neostriatum and Substantia Nigra

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Taurine 2

Part of the book series: Advances in Experimental Medicine and Biology ((AEMB,volume 403))

Abstract

Taurine has been shown to fulfil many of the criteria of a neurotransmitter in the basal ganglia. The neostriatum (STR) and substantia nigra (SN) contain high levels of taurine and its synthetic enzyme sulfinoalanine decarboxylase (EC 4.1.1.29, commonly referred to as cysteine sulfinic acid decarboxylase, CSDI)19, 29, 34, 41, 43, 45. The presence of a high affinity uptake system for taurine has been detected in both the STR11, 29 and SN14. Furthermore, uptake and release studies of exogenous radiolabelled taurine suggest that neurones identified as medium-size densely spiny striatonigral neurones contain taurine and release it at their terminals in the SN15 (see Table 1).

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Authors and Affiliations

  1. Dipartimento di Farmacologia Preclinica e Clinica “M. Aiazzi Mancini”, Università degli Studi di Firenze, Viale G.B. Morgagni 65, 50134, Florence, Italy

    Loria Bianchi, Francesca Galeffi & Laura Della Corte

  2. MRC Anatomical Neuropharmacology Unit, Mansfield Road, Oxford, OX1 3TH, UK

    John P. Bolam

  3. Istituto di Scienze Farmacologiche, Università degli Studi di Siena, Via E.S. Piccolomini 170, 53100, Siena, Italy

    Maria Frosini, Mitri Palmi & Gianpietro Sgaragli

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  1. Loria Bianchi
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Editors and Affiliations

  1. University of Arizona, Tucson, Arizona, USA

    Ryan J. Huxtable

  2. Osaka University Osaka, Osaka, Japan

    Junichi Azuma  & Akemichi Baba  & 

  3. Kyoto Prefectural University of Medicine, Kyoto, Japan

    Kinya Kuriyama  & Masao Nakagawa  & 

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Bianchi, L. et al. (1996). In Vivo Release of Taurine from Rat Neostriatum and Substantia Nigra. In: Huxtable, R.J., Azuma, J., Kuriyama, K., Nakagawa, M., Baba, A. (eds) Taurine 2. Advances in Experimental Medicine and Biology, vol 403. Springer, Boston, MA. https://doi.org/10.1007/978-1-4899-0182-8_46

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  • DOI: https://doi.org/10.1007/978-1-4899-0182-8_46

  • Publisher Name: Springer, Boston, MA

  • Print ISBN: 978-1-4899-0184-2

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