Taurine 2 pp 427-433 | Cite as

In Vivo Release of Taurine from Rat Neostriatum and Substantia Nigra

  • Loria Bianchi
  • John P. Bolam
  • Francesca Galeffi
  • Maria Frosini
  • Mitri Palmi
  • Gianpietro Sgaragli
  • Laura Della Corte
Part of the Advances in Experimental Medicine and Biology book series (AEMB, volume 403)

Abstract

Taurine has been shown to fulfil many of the criteria of a neurotransmitter in the basal ganglia. The neostriatum (STR) and substantia nigra (SN) contain high levels of taurine and its synthetic enzyme sulfinoalanine decarboxylase (EC 4.1.1.29, commonly referred to as cysteine sulfinic acid decarboxylase, CSDI)19, 29, 34, 41, 43, 45. The presence of a high affinity uptake system for taurine has been detected in both the STR11, 29 and SN14. Furthermore, uptake and release studies of exogenous radiolabelled taurine suggest that neurones identified as medium-size densely spiny striatonigral neurones contain taurine and release it at their terminals in the SN15 (see Table 1).

Keywords

Toxicity HPLC Dioxide Attenuation Dopamine 

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Copyright information

© Springer Science+Business Media New York 1996

Authors and Affiliations

  • Loria Bianchi
    • 1
  • John P. Bolam
    • 2
  • Francesca Galeffi
    • 1
  • Maria Frosini
    • 3
  • Mitri Palmi
    • 3
  • Gianpietro Sgaragli
    • 3
  • Laura Della Corte
    • 1
  1. 1.Dipartimento di Farmacologia Preclinica e Clinica “M. Aiazzi Mancini”Università degli Studi di FirenzeFlorenceItaly
  2. 2.MRC Anatomical Neuropharmacology UnitOxfordUK
  3. 3.Istituto di Scienze FarmacologicheUniversità degli Studi di SienaSienaItaly

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