Taurine 2 pp 37-50 | Cite as

The Effects of Taurine in a Rodent Model of Aging

  • Ralph DawsonJr.
  • Baerbel Eppler
  • Tucker A. Patterson
  • Debbie Shih
  • Steve Liu
Part of the Advances in Experimental Medicine and Biology book series (AEMB, volume 403)


A number of excellent review articles have examined the various physiological roles of taurine in adult and developing organisms19, 20, 39. A conclusion that can be drawn from these various reviews is that there is a dearth of information on the role of taurine in aging and senescence. A few studies have examined the tissue content of taurine in aging animal models. In general taurine content seems to decline modestly with advanced age. What is unclear is whether the aging process may increase the demand for the protective and regulatory actions of taurine in cellular homeostasis. This article will briefly review what is known about changes in taurine content and function during senescence and describe our recent studies of taurine supplementation using a common rodent model of aging. We will also discuss the potential consequences of a diminished cytoprotective role of taurine in advanced aging due to a age-related decrement in taurine homeostasis.


Adult Control Taurine Supplementation Taurine Concentration Taurine Release Taurine Content 


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  1. 1.
    Albrecht, I, Bender, A.S., and Norenberg, M.D. 1994, Ammonia stimulates the release of taurine from cultured astrocytes, Brain Res. 660:288–292.CrossRefGoogle Scholar
  2. 2.
    Banay-Schwartz, M., Lajtha, A., and Palkovits, M. 1989, Changes with aging in the levels of amino acids in rat CNS structural elements. II. Taurine and small neutral amino acids, Neurochem.Res. 14:563–570.CrossRefGoogle Scholar
  3. 3.
    Benedetti, M.S., Russo, A., Marrari, P., and Dostert, P. 1991, Effects of aging on the content in sulfur-containing amino acids in rat brain, J. Neural Transm. 86:191–203.CrossRefGoogle Scholar
  4. 4.
    Benkovic, S.A. and Connor, J.R. 1993, Ferritin, transferrin, and iron in selected regions of the adult and aged rat brain, J.Comp. Neurol. 338:97–113.CrossRefGoogle Scholar
  5. 5.
    Coleman, G.L., Barthold, S.W., Osbaldiston, G.W., Foster, S.J., and Jonas, A.M. 1977, Pathological changes during aging in barrier-reared Fischer 344 male rats, J.Gerontol. 32:258–278.CrossRefGoogle Scholar
  6. 6.
    Corman, B., Pratz, J., and Poujeol, P. 1985, Changes in anatomy, glomerular filtration, and solute excretion in aging rat kidney, Am. J. Physiol. 248:R282–R287.Google Scholar
  7. 7.
    Dawson, R., Patterson, T.A., and Eppler, B. 1995, Endogenous excitatory amino acid release from brain slices and astrocyte cultures evoked by trimethyltin and other neurotoxic agents, Neurochem.Res. 20:847–858.CrossRefGoogle Scholar
  8. 8.
    Dawson, R. and Wallace, D.R. 1992, Kainic acid-induced seizures in aged rats: neurochemical correlates, Brain Res.Bull. 29:459–468.CrossRefGoogle Scholar
  9. 9.
    Dawson, R. and Wallace, D.R. 1992, Taurine content in tissues from aged Fischer 344 rats, Age, 15:73–81.CrossRefGoogle Scholar
  10. 10.
    Dawson, R., Wallace, D.R., and Meldrum, M.J. 1989, Endogenous glutamate release from frontal cortex of adult and aged rats, Neurobiol. Aging, 10:665–668.CrossRefGoogle Scholar
  11. 11.
    Dawson, R., Jr., Wallace, D.R., and King, M.J. 1990, Monoamine and amino acid content in brain regions of Brattleboro rats, Neurochem.Res. 15:755–761.CrossRefGoogle Scholar
  12. 12.
    Donzanti, B.A. and Ung, A.K. 1990, Alterations in neurotransmitter amino acid content in the aging rat striatum are subregion dependent, Neurobiol. Aging, 11:159–162.CrossRefGoogle Scholar
  13. 13.
    Fierabracci, V, Del Roso, A., Novelli, M., Masiello, P., Fosella, P.V., and Bergamini, E. 1990, Age-related changes in amino acid metabolism in the rat, in: “Protein Metabolism in Aging”, Anonymous Wiley-Liss, New York.Google Scholar
  14. 14.
    Friedman, A.L., Albright, P.W., Gusowski, N., Padilla, M., and Chesney, R.W. 1983, Renal adaptation to alteration in dietary amino acid intake, Am. J.Physiol. 245:F159–F166.Google Scholar
  15. 15.
    Gibson, G.E. and Peterson, C. 1987, Calcium and the aging nervous system, Neurobiol. Aging, 8:329–343.CrossRefGoogle Scholar
  16. 16.
    Goldstein, R.S., Tarloff, J.B., and Hook, J.B. 1988, Age-related nephropathy in laboratory rats, FASEB J. 2:2241–2251.Google Scholar
  17. 17.
    Harman, D. 1988, Free radicals and aging, Mol.Cell.Biochem. 84:155–161.CrossRefGoogle Scholar
  18. 18.
    Heikkila, R.E. and Cabbat, F.S. 1978, The stimulation of 6-hydroxydopamine autoxidation by bivalent copper: potential importance in neurotoxic process, Life Sci. 23:33–38.CrossRefGoogle Scholar
  19. 19.
    Huxtable, R.J. 1989, Taurine in the central nervous system and the mammalian actions of taurine, Prog.Neurobiol. 32:471–533.CrossRefGoogle Scholar
  20. 20.
    Huxtable, R.J. 1992, Physiological actions of taurine, Physiol.Rev. 72:101–163.Google Scholar
  21. 21.
    Kirzinger, S.S. and Fonda, M.L. 1978, Glutamine and ammonia metabolism in the brains of senescent mice, Exp.Gerontol. 13:255–261.CrossRefGoogle Scholar
  22. 22.
    LeBel, C.L. and Bondy, S.C. 1992, Oxidative damage and cerebral aging, Prog.Neurobiol. 38:601–609.CrossRefGoogle Scholar
  23. 23.
    Luine, V., Bowling, D., and Hearns, M. 1990, Spatial memory deficits in aged rats: contributions of monoaminergic systems, Brain Res. 537:271–278.CrossRefGoogle Scholar
  24. 24.
    Magnoni, M.S., Govoni, S., Battaini, F., and Trabucchi, M. 1991, The aging brain: protein phosphorylation as a target of changes in neuronal function, Life Sci. 48:373–385.CrossRefGoogle Scholar
  25. 25.
    Massie, H.R., Williams, T.R., and DeWolfe, L.K. 1989, Changes in taurine in aging fruit flies and mice, Exp.Gerontol. 24:57–65.CrossRefGoogle Scholar
  26. 26.
    Meldrum, M.J., Tu, R., Patterson, T.A., Dawson, R., and Petty, T. 1994, The effect of taurine on blood pressure, and urinary sodium, potassium and calcium excretion, in: “Taurine in Health and Disease”, Huxtable, R. and Michalk, D.V. eds., Plenum Press, New York.Google Scholar
  27. 27.
    Milakofsky, L., Hare, T.A., Miller, J.M., and Vogel, W.H. 1984, Comparison of amino acid levels in rat blood obtained by catheterization and decapitation, Life Sci. 34:1333–1340.CrossRefGoogle Scholar
  28. 28.
    Milakofsky, L., Harris, N., and Vogel, W.H. 1993, Effect of repeated stress on plasma catecholamines and taurine in young and old rats, Neurobiol. Aging, 14:359–366.CrossRefGoogle Scholar
  29. 29.
    Miller, D.M., Buettner, G.R., and Aust, S.D. 1990, Transition metals as catalysts of “autoxidation” reactions, Free Radical Biol.Med. 8:95–108.CrossRefGoogle Scholar
  30. 30.
    Monks, T.J., Hanzlik, R.P., Cohen, G.M., Ross, D., and Graham, D.G. 1992, Quinone chemistry and toxicity, Toxicol.Appl.Pharmacol. 112:2–16.CrossRefGoogle Scholar
  31. 31.
    Nishio, S., Negoro, S., Hosokawa, T., Hara, H., Tanaka, T., Deguchi, Y., Ling, J., Awata, N., Azuma, J., Aoike, A., Kawai, K., and Kishimoto, S. 1990, The effect of taurine on age-related immune decline in mice: the effect of taurine on T cell and B cell proliferative response under costimulation with ionomycin and phorbol myristate acetate, Mech.Aging Dev. 52:125–139.CrossRefGoogle Scholar
  32. 32.
    Oja, S.S., Holopainen, I., and Kontro, P. 1990, Stimulated taurine release from different brain preparations: Changes during development and aging, in: “Taurine: Functional Neurochemistry, Physiology, and Cardiology”, Pasantes-Morales, H., Martin, D.L., Shain, W. and del Río, R.M. eds., Wiley-Liss, New York, pp. 277–287.Google Scholar
  33. 33.
    Ooboshi, H., Sadoshima, S., Yao, H., Ibayashi, S., Matsumoto, T., Uchimura, H., and Fujishima, M. 1995, Ischemia-induced release of amino acids in the hippocampus of aged hypertensive rats, J.Cereb.Blood Flow Metab. 15:227–234.CrossRefGoogle Scholar
  34. 34.
    Palkovits, M., Banay-Schwartz, M., and Lajtha, A. 1990, Taurine levels in brain nuclei of young adult and aging rats, in: “Taurine: Functional Neurochemistry, Physiology, and Cardiology”, Pasantes-Morales, H., Martin, D.L., Shain, W. and del Río, R.M. eds., Wiley-Liss, New York, pp. 45–51.Google Scholar
  35. 35.
    Pasantes-Morales, H., Wright, C.E., and Gaull, G.E. 1985, Taurine protection of lymphoblastoid cells from iron-ascorbate induced damage, Biochem.Pharmacol. 34:2205–2206.CrossRefGoogle Scholar
  36. 36.
    Pierno, S., DeLuca, A., Roselli, A., Degiorgi, A., Huxtable, R.J., and Conte Camerino, D. 1996, Effects of chronic taurine treatment on the electrical and contractile properties of skeletal muscle fibers of aged rats, in: “Taurine: Basic and Clinical Aspects”, Huxtable, R.J., Azuma, J., Kuriyama, K., Nakagawa, M. and Baba, A. eds., Plenum Publishing Co. New York.Google Scholar
  37. 37.
    Rozen, R. and Scriver, C.R. 1982, Renal transport of taurine adapts to perturbed taurine homeostasis, Proc.Natl.Acad.Sci.USA, 79:2101–2105.CrossRefGoogle Scholar
  38. 38.
    Shimokawa, I., Higami, Y., Hubbard, G.B., McMahan, CA., Masoro, E.J., and Yu, B.P 1993, Diet and the suitability of the male Fischer 344 rat as a model for aging research, J.Gerontol. 48:B27–B32.CrossRefGoogle Scholar
  39. 39.
    Sturman, J.A. 1993, Taurine in development, Physiol.Rev. 73:119–147.Google Scholar
  40. 40.
    Timiras, P.S., Hudson, D.B., and Oklund, S. 1973, Changes in central nervous system free amino acids with development and aging, Prog.Brain Res. 40:267–275.CrossRefGoogle Scholar
  41. 41.
    Trachtman, H., Del Pizzo, R., Futterweit, S., Levine, D., Rao, P.S., Valderrama, E., and Sturman, J.A. 1992, Taurine attenuates renal disease in chronic puromycin aminonucleoside nephropathy, Am.J.Physiol.Renal, Fluid Electrolyte Physiol. 262:F117–F123.Google Scholar
  42. 42.
    Trachtman, H., Lu, P., and Sturman, J.A. 1993, Immunohistochemical localization of taurine in rat renal tissue: Studies in experimental disease states, J.Histochem.Cytochem. 41:1209–1216.CrossRefGoogle Scholar
  43. 43.
    Trachtman, H., Pizzo, R.D., Rao, P., Rujikarn, N., and Sturman, J.A. 1989, Taurine lowers blood pressure in the spontaneously hypertensive rat by a catecholamine independent mechanism, Am.J.Hyperten. 2:909–912.Google Scholar
  44. 44.
    Tyce, G.M. and Wong, K. 1980, Conversion of glucose to neurotransmitter amino acids in the brains of young and aging rats, Exp.Gerontol. 15:527–532.CrossRefGoogle Scholar
  45. 45.
    Wallace, D.R. and Dawson, R. 1992, Ammonia regulation of phosphate-activated glutaminase displays regional variation and impairment in the brain of aged rats, Neurochem.Res. 17:1113–1122.CrossRefGoogle Scholar
  46. 46.
    Wallace, D.R. and Dawson, R., Jr. 1990, Decreased plasma taurine in aged rats, Gerontology, 36:19–27.CrossRefGoogle Scholar
  47. 47.
    Waterfield, C.J., Turton, J.A., Scales, M.D.C., and Timbrell, J.A. 1993, The correlation between urinary and liver taurine levels and between pre-dose urinary taurine and liver damage, Toxicology, 77:1–5.CrossRefGoogle Scholar
  48. 48.
    Wright, C.E., Tallan, H.H., Lin, Y.Y., and Gaull, G.E. 1986, Taurine: biological update, Ann.Rev.Biochem. 55:427–453.CrossRefGoogle Scholar
  49. 49.
    Yamamoto, J., Akabane, S., Yoshimi, H., Nakai, M., and Ikeda, M. 1985, Effects of taurine on stressevoked hemodynamic and plasma catecholamine changes in spontaneous hypertensive rats, Hypertension, 7:913–922.CrossRefGoogle Scholar

Copyright information

© Springer Science+Business Media New York 1996

Authors and Affiliations

  • Ralph DawsonJr.
    • 1
  • Baerbel Eppler
    • 1
  • Tucker A. Patterson
    • 1
  • Debbie Shih
    • 1
  • Steve Liu
    • 1
  1. 1.Department of PharmacodynamicsCollege of Pharmacy, University of FloridaGainesvilleUSA

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