Taurine 2 pp 315-325 | Cite as

Effect of Taurine on Toxicity of the Pyrrolizidine Alkaloid Monocrotaline in Rats

  • Chong Chao Yan
  • Ryan J. Huxtable
Part of the Advances in Experimental Medicine and Biology book series (AEMB, volume 403)


The pyrrolizidine alkaloid (PA), monocrotaline, is found in a variety of Crotalaria species in the legume family13. It has been responsible for a large number of human intoxications, most dramatically in the Caribbean nations of Jamaica3, 11, 31. For many years, monocrotaline-induced veno-occlusive disease of the liver was endemic, due to the use of the leaves of C. spectabilis in the preparation of the so-called “bush teas” that were commonly consumed. It was not until the 1950s that the cause of the condition was established2 and control measures instituted.


Pulmonary Arterial Hypertension Pyrrolizidine Alkaloid Decrease Body Weight Gain Serum Amino Acid Concentration Monocrotaline Injection 
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Copyright information

© Springer Science+Business Media New York 1996

Authors and Affiliations

  • Chong Chao Yan
    • 1
  • Ryan J. Huxtable
    • 1
  1. 1.Department of Pharmacology, College of MedicineUniversity of ArizonaTucsonUSA

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