Taurine 2 pp 297-304 | Cite as

Effect of Taurine on Angiotensin II-Induced Expression of Immediate Early Response Genes in Primary Cultured Neonatal Rat Heart Cells

  • Kyoko Takahashi
  • Hitoshi Hashimoto
  • Akemichi Baba
  • Stephen W. Schaffer
  • Junichi Azuma
Part of the Advances in Experimental Medicine and Biology book series (AEMB, volume 403)


Taurine has been used successfully to treat patients with congestive heart failure2. Recently, it has been established that one of the important factors contributing to the development of cardiac hypertrophy and heart failure is angiotensin II3, 9, 14. Angiotensin II is a peptide hormone that plays a major role in the regulation of fluid balance, blood pressure and cardiac function. Its direct cardiac effects include modulation of Na+, H+ and Ca2+ transport, increasing heart rate and mechanical function, stimulation of protein synthesis and enhancing uptake and utilization of glucose3, 9.


Cardiac Myocytes Cardiac Cell Early Response Gene Beating Rate Taurine Treatment 


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Copyright information

© Springer Science+Business Media New York 1996

Authors and Affiliations

  • Kyoko Takahashi
    • 1
  • Hitoshi Hashimoto
    • 2
  • Akemichi Baba
    • 2
  • Stephen W. Schaffer
    • 3
  • Junichi Azuma
    • 1
  1. 1.Department of Clinical Evaluation of Medicines and TherapeuticsOsaka University, Faculty of Pharmaceutical SciencesOsakaJapan
  2. 2.Department of PharmacologyOsaka University, Faculty of Pharmaceutical SciencesOsakaJapan
  3. 3.Department of PharmacologyUniversity of South Alabama, School of MedicineMobileUSA

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