Effects of Chronic Taurine Treatment on the Electrical and Contractile Properties of Skeletal Muscle Fibers of Aged Rats
Taurine has an important role in stabilizing mammalian skeletal muscle membrane. Indeed previous studies have shown that in vitro application of taurine reduces fiber excitability by a specific and concentration-dependent increase of resting Cl− conductance (GCl)4, 20, this parameter largely contributing to the electrical stability of sarcolemma21. A better evaluation of the role of taurine in skeletal muscle derives from studies on taurine-de-pleted muscles. Indeed chronic treatment with guanidinoethane sulfonate (GES), an inhibitor of taurine transport15, caused a fall in muscular taurine content and a marked decrease of GCl along with an increase of excitability of rat skeletal muscle fibers9, 19. Furthermore we found that the excitation-contraction coupling process of taurine-depleted muscles was significantly changed, the GES-treated fibers contracting at more negative potentials than normal controls9.
KeywordsExtensor Digitorum Longus Skeletal Muscle Fiber Mechanical Threshold Aged Muscle Taurine Content
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