Effect of Treatment with β-Agonists on Tissue and Urinary Taurine Levels in Rats
Administration of clenbuterol to rats in the drinking water over a four day period increased incorporation of [3H]leucine into muscle protein but did not result in an increase in body or muscle weight. However, both urinary and liver taurine were significantly reduced at the highest dose of clenbuterol (2 mg. kg−1 day−1). Salbutamol also reduced urinary levels of taurine in both rats and humans. The reduction in the body pool of taurine caused by β-agonists may be of concern as taurine has been shown to have protective properties.
KeywordsMuscle Protein Serum Total Protein Muscle Weight Adrenoceptor Agonist Leucine Incorporation
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