Taurine and Water Channels are Co-Localized in Renal Tubule Cells and Other Tissues
One of the best established roles of taurine is that of an osmoregulator7. Many cell types have been shown to sustain a loss of taurine upon exposure to hypoosmotic stress11 while an increased uptake of this amino acid can be induced by hyperosmotic conditions12. The latter effect has been demonstrated in renal cells in culture, thus supporting the notion that taurine acts as an organic osmolyte in the kidney along with polyhydric alcohols and methylamines5.
KeywordsGold Particle Water Channel Tubule Cell Intercalate Cell Collect Duct
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- 1.Agre, P., Brown, D. and Nielsen, S. 1995, Aquaporin water channels: unanswered questions and unresolved controversies, Curr. Opin. Cell Biol., in press.Google Scholar
- 4.Chou, C-L. and Knepper, M.A. 1992, In vitro perfusion of chinchilla thin limb segments: Segmentation and osmotic water permeability. Am. J. Physiol. 263: F417–F426.Google Scholar
- 5.Garcia-Perez, A. and Burg, M.B. 1991, Renal medullary organic osmolytes, Physiol. Rev. 71:1081–1115.Google Scholar
- 7.Huxtable, R.J. 1992, The physiological action of taurine, Physiol. Rev. 72:101–163.Google Scholar
- 8.Madsen, S., Ottersen, O.P., Storm-Mathisen, J. and Sturman, J.A. 1990, Immunocytochemical localization of taurine: Methodological aspects, in: “Taurine: Functional Neurochemistry, Physiology, and Cardiology,” Pasantes-Morales, H., Martin, D.L., Shain, W. and Martin Del Rio, R. eds., Wiley-Liss, New York, pp. 37–44.Google Scholar
- 13.Wade, J.B., Stanton, B.A. and Brown, D. 1992, Structural correlates of transport in distale tubule and collecting duct segments, in: “Handbook of Physiology: Renal Physiology,” Windhager, E.E. ed., Oxford University Press, New York, pp. 169–226.Google Scholar
- 14.Wang, B.L. and Larsson, L.I. 1985, Simultaneous demonstration of multiple antigens by indirect immunofluorescence or immunogold staining. Novel light and electron microscopic double and triple staining method employing primary antibodies from the same species, Histochemistry 83:47–56.CrossRefGoogle Scholar