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Taurine 2 pp 135-145 | Cite as

Effect of the Pyrrolizidine Alkaloid Monocrotaline on Taurine and Sulfur Amino Acid Metabolism in the Rat Liver

  • Chong Chao Yan
  • Ryan J. Huxtable
Part of the Advances in Experimental Medicine and Biology book series (AEMB, volume 403)

Abstract

Pyrrolizidine alkaloids (PAs) comprise a large group of plant toxins, characteristically producing veno-occlusive disease of the liver as a result of hepatic bioactivation to pyrrolic dehydroalkaloids4, 5 (Fig. 1). These pyrrolic metabolites are highly reactive alkylating agents, with aqueous half-lives of only a few seconds1. Dehydroalkaloids are detoxified in the liver by conjugation with glutathione (GSH) to yield 7-glutathionyl-6, 7-di-hydro-l-hydroxymethyl-5H-pyrrolizine (GSDHP; Fig. 1). Following exposure in vivo to a PA, or perfusion of an isolated liver in vitro, high levels of GSDHP are released into the bile11, 13.

Keywords

Perfuse Liver Sulfur Amino Acid Pyrrolizidine Alkaloid Taurine Supplementation Ehrlich Reagent 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

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Copyright information

© Springer Science+Business Media New York 1996

Authors and Affiliations

  • Chong Chao Yan
    • 1
  • Ryan J. Huxtable
    • 1
  1. 1.Department of Pharmacology, College of MedicineUniversity of ArizonaTucsonUSA

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