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Taurine 2 pp 99-106 | Cite as

Significance of Taurine Conjugation of Bile Acid in the Biliary Excretion of Bilirubin

  • Junichi Yamao
  • Yoshinobu Matsumura
  • Yoichi Hokaze
  • Masahide Yoshikawa
  • Norie Umemoto
  • Yuji Matsui
  • Hiroshi Fukui
  • Tadasu Tsujii
Part of the Advances in Experimental Medicine and Biology book series (AEMB, volume 403)

Abstract

Almost all bile acids are conjugated with either taurine or glycine. The conjugates are more potent cholelogues than the unconjugated bile acids. Previously, we have confirmed that administration of taurine increased bile flow and biliary excretion of bile acids in rats with cholestasis induced by α-naphthylisothiocyanate6. Moreover, we found that administration of taurine shortened duration of jaundice in patients with acute hepatitis4. These results suggest a possibility that taurine may accelerate biliary excretion of bilirubin. In the present study, we investigated the effect of taurine on the biliary excretion of bilirubin in normal and mutant hyperbilirubinuric rats4.

Keywords

Bile Acid Cholic Acid Biliary Excretion Continuous Intravenous Infusion Sulfur Amino Acid 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

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References

  1. 1.
    Ekdahl, P.H., Gottfreis, A., and Scherstein, T. 1965, A sensitive method for the study of bile acid conjugation in homogenates of human liver biopsies, ScandinavJ.Clin.Lab.Investigation, 17:103–109.CrossRefGoogle Scholar
  2. 2.
    Gaubutt, J.T., Heaton, K.W., Lack, L. and Tyor, M.P. 1969, Increased ratio of glycine-to-taurine-conju-gated bile salts in patients with ileal disorders, Gastroenterol. 56:711–720.Google Scholar
  3. 3.
    Kitani, K. and Kanai, S. 1982, Effect of ursodeoxycholate on the bile flow in the rat, Life Sci. 31:1973–1985.CrossRefGoogle Scholar
  4. 4.
    Matsuyama, Y., Morita, T., Higuchi, M., Tsujii, T. and Iwata, H. 1983, The effect of taurine administration on patients with acute hepatitis, in: “Sulfur Amino Acids: Biochemical and Clinical Aspects”, Kuriyama, K., Huxtable, R.J. and Iwata, H. eds., Alan R. Liss, Inc., New York, pp. 461–468.Google Scholar
  5. 5.
    Shaffer, J.E. and Kocsis, J.J. 1981, Taurine mobilizing effects of beta alanine and other inhibitors of taurine transport, Life Sci. 28:2727–2736.CrossRefGoogle Scholar
  6. 6.
    Tsujii, T., Matsuyama, Y., and Takagi, M. 1978, Effect of taurine and steroid on the biliary excretion of experimental intraheptic cholestasis in rats, Sulfur Amino Acids, 1:289–301.Google Scholar

Copyright information

© Springer Science+Business Media New York 1996

Authors and Affiliations

  • Junichi Yamao
    • 1
  • Yoshinobu Matsumura
    • 1
  • Yoichi Hokaze
    • 1
  • Masahide Yoshikawa
    • 1
  • Norie Umemoto
    • 1
  • Yuji Matsui
    • 1
  • Hiroshi Fukui
    • 1
  • Tadasu Tsujii
    • 1
  1. 1.Third Department of Internal MedicineNara Prefectural University of MedicineKashiharaJapan

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