Effect of a Potent Platelet-Activating Factor Antagonist, WEB-2086, on Asthma
Platelet-activating factor (PAF) has been suggested to be an important chemical mediator in bronchial asthma1). When given by inhalation, PAF produces short-term bronchoconstriction in both normal2) and asthmatic subjects2,3), increases airway reactivity in normal volunteers4,5), stimulates leukotriene and thromboxane A2 production in asthmatics6), and also worsens gas exchange in mild asthma7). In aminal models, it has been reported that exogenous PAF causes bronchoconstriction, microvascular leakage, mucous hypersecretion, an increase in bronchial responsiveness, and eosinophil recruitment into the airways of guinea pigs1). Thus, PAF induces various pathophysiologic changes relevant to bronchial asthma.
KeywordsPlatelet Activate Factor Allergy Clin Immunol Baseline Period Daily Variability Platelet Activate Factor Antagonist
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