Abstract
In inflammatory cells, PAF is considered to be synthesized via the remodeling pathway1). Activation of phospholipase A2 releases sn-2 fatty acids, predominantly arachidonic acid, which is metabolized to prostanoids by cyclooxygenase and lipoxygenase. The two different lipid mediators, PAF and prostanoids, are produced from a common precursor in membrane phospholipids when PAF is produced via the remodeling pathway. Because PAF and prostanoids are potent, biologically active mediators, we considered that their production is interdependent.
This is a preview of subscription content, log in via an institution to check access.
Access this chapter
Tax calculation will be finalised at checkout
Purchases are for personal use only
Preview
Unable to display preview. Download preview PDF.
References
Albert, D. H. and Snyder, F.: J. Biol. Chem., 258: 97–102.
Ohuchi, K., Sugawara, T., Watanabe, M., Hirasawa, N., Tsurufuji, S., Fujiki, H., Christensen, S. B. and Sugimura, T.: Br. J. Pharmacol. 94: 917–923, 1988.
Ohuchi, K., Sugawara, T., Watanabe, M., Hirasawa, N., Tsurufuji, S., Fujiki, H., Sugimura, T. and Christensen, S. B.: J. Cancer Res. Clin. Oncol. 113: 319–324, 1987.
Watanabe, M., Watanabe, T., Hirasawa, N., Mue, S.,Muramatsu, S., Matsushita, Y., Takahagi, H., Braquet, P., Broquet, P., Levine, L. and Ohuchi, K.: J. Chromatogr. 597: 309–314, 1992.
Watanabe, M., Yamada, M., Mue, S. and Ohuchi, K.: Br. J. Pharmacol. 116: in press, 1995.
Author information
Authors and Affiliations
Editor information
Editors and Affiliations
Rights and permissions
Copyright information
© 1996 Springer Science+Business Media New York
About this chapter
Cite this chapter
Yamada, M., Watanabe, M., Mue, S., Ohuchi, K. (1996). Platelet-Activating Factor Production in the Stimulated Macrophages is Enhanced by the Cyclooxygenase Inhibitors. In: Nigam, S., Kunkel, G., Prescott, S.M. (eds) Platelet-Activating Factor and Related Lipid Mediators 2. Advances in Experimental Medicine and Biology, vol 416. Springer, Boston, MA. https://doi.org/10.1007/978-1-4899-0179-8_6
Download citation
DOI: https://doi.org/10.1007/978-1-4899-0179-8_6
Publisher Name: Springer, Boston, MA
Print ISBN: 978-1-4899-0181-1
Online ISBN: 978-1-4899-0179-8
eBook Packages: Springer Book Archive