Platelet-Activating Factor Production in the Stimulated Macrophages is Enhanced by the Cyclooxygenase Inhibitors
In inflammatory cells, PAF is considered to be synthesized via the remodeling pathway1). Activation of phospholipase A2 releases sn-2 fatty acids, predominantly arachidonic acid, which is metabolized to prostanoids by cyclooxygenase and lipoxygenase. The two different lipid mediators, PAF and prostanoids, are produced from a common precursor in membrane phospholipids when PAF is produced via the remodeling pathway. Because PAF and prostanoids are potent, biologically active mediators, we considered that their production is interdependent.
KeywordsArachidonic Acid Conditioned Medium PGE2 Production Cyclooxygenase Inhibitor Dibutyryl cAMP
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