Characterization of Plasmalogen-Selective Phospholipase A2 from Bovine Brain
Plasmalogens are hydrolyzed by a plasmalogen-selective phospholipase A2. This enzyme, purified from bovine brain, does not require Ca2+ and is localized in cytosol. It has a molecular mass of 39 kDa and is strongly inhibited by glycosaminoglycans, gangliosides, and sialoglycoproteins. These molecules may be involved in the regulation of its enzymic activity. Plasmalogen-selective phospholipase A2 plays an important role in the release of free fatty acids and platelet-activating factor during trauma.
KeywordsBovine Brain Vasopressin Receptor Excitatory Amino Acid Receptor Smooth Muscle Cell Line Suicide Inhibitor
Unable to display preview. Download preview PDF.
- Farooqui, A.A., Yang, H.-C., and Horrocks, L.A. 1995, Plasmalogens, phospholipases A2, and signal transduction, Brain Res. Rev. (in press).Google Scholar
- Horrocks, L.A. and Sharma, M. 1982, Plasmalogens and 0-alkyl glycerophospholipids, in: “Phospholipids, New Comprehensive Biochemistry, Vol. 4,” 51–93Google Scholar
- J.N. Hawthorne, G.B. Ansell, eds., Elsevier Biomedical Press, Amsterdam.Google Scholar