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Platelet-Activating Factor (PAF): Signalling and Adhesion in Cell-Cell Interactions

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Platelet-Activating Factor and Related Lipid Mediators 2

Part of the book series: Advances in Experimental Medicine and Biology ((AEMB,volume 416))

Abstract

PAF is a signalling molecule1 that mediates interactions between cells2. Cell-cell interactions are critical in both physiologic and pathologic processes3,4. Many of the best-characterized effects of PAF involve cellular signalling in the inflammatory and vascular systems, but it also accomplishes signalling functions in the reproductive system, the brain, and in many other organs2. It has the remarkable property of being able to act as an endocrine, paracrine, autocrine, or juxtacrine signal depending on the cell of origin and the specific conditions under which it interacts with target cells5. The amphipathic properties of PAF and its ability to interact with both lipids and proteins contribute to this versatility.

Supported by the Nora Eccles Treadwell Foundation, individual grants from the National Institutes of Health and the Department of Veterans Affairs Medical Research Fund, an NIH Training Grant in Cellular and Physiologic Responses in Lung Disease, an NIH Special Center of Research in ARDS, and an NIH Center of Excellence in Molecular Hematology.

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Author information

Authors and Affiliations

  1. Nora Eccles Harrison Cardiovascular Research and Training Institute, USA

    G. A. Zimmerman, M. R. Elstad, D. E. Lorant, T. M. McIntyre, Matthew K. Topham, A. S. Weyrich & Ralph E. Whatley

  2. Program in Human Molecular Biology and Genetics, USA

    S. M. Prescott

  3. Departments of Biochemistry, University of Utah, Salt Lake City, Utah, USA

    M. R. Elstad & S. M. Prescott

  4. Departments of Medicine, University of Utah, Salt Lake City, Utah, USA

    G. A. Zimmerman, M. R. Elstad, T. M. McIntyre, S. M. Prescott, Matthew K. Topham, A. S. Weyrich & Ralph E. Whatley

  5. Departments of Pathology, University of Utah, Salt Lake City, Utah, USA

    T. M. McIntyre

  6. Departments of Pediatrics, University of Utah, Salt Lake City, Utah, USA

    D. E. Lorant

Authors
  1. G. A. Zimmerman
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  2. M. R. Elstad
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  3. D. E. Lorant
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  4. T. M. McIntyre
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  5. S. M. Prescott
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  6. Matthew K. Topham
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  7. A. S. Weyrich
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  8. Ralph E. Whatley
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Editor information

Editors and Affiliations

  1. Free University Berlin, Berlin, Germany

    Santosh Nigam  & Gert Kunkel  & 

  2. University of Utah, Salt Lake City, Utah, USA

    Stephen M. Prescott

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© 1996 Springer Science+Business Media New York

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Zimmerman, G.A. et al. (1996). Platelet-Activating Factor (PAF): Signalling and Adhesion in Cell-Cell Interactions. In: Nigam, S., Kunkel, G., Prescott, S.M. (eds) Platelet-Activating Factor and Related Lipid Mediators 2. Advances in Experimental Medicine and Biology, vol 416. Springer, Boston, MA. https://doi.org/10.1007/978-1-4899-0179-8_47

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  • DOI: https://doi.org/10.1007/978-1-4899-0179-8_47

  • Publisher Name: Springer, Boston, MA

  • Print ISBN: 978-1-4899-0181-1

  • Online ISBN: 978-1-4899-0179-8

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