Epimer-Specific Actions of Hepoxilins A3 and B3 on PAF- and Bradykinin-Evoked Vascular Permeability in the Rat Skin in Vivo
The two epimers of hepoxilins A3 (8R and 8S) and B3 (l0R and l0S) were tested for effects on vascular permeability in the rat skin assay, a model for acute inflammation. Results showed epimer-specific effects, the R isomer being active, the S isomer being essentially inactive. While the hepoxilins on their own, at a dose of 20–40 ng/injection intradermally were essentially inactive, they potentiated the actions of bradykinin (both HxA3 and B3 were active) and PAF (only 10R was active) coinjected with the hepoxilins. These results suggest that hepoxilins may mediate (amplify) the actions of inflammatory mediators.
KeywordsVascular Permeability Platelet Activate Factor Evans Blue Dorsal Skin Research Institute Hospital
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