Role of Platelet-Activating Factor in Skeletal Muscle Ischemia-Reperfusion Injury
Blood flow can be restored to limbs after 1 to 2 hours of ischemia with the expectation that the limbs will survive and be functional. Adverse changes may occur during reperfusion of skeletal muscle which has been ischemic for 3 hours or more. These changes, ischemia-reperfusion injury (IRI), can include endothelial cell swelling, increased micròvascular permeability, leukocyte endothelial adhesion, vascular thrombosis, altered vascular resistance, no reflow phenomenon, altered monocyte/neutrophil function and even death of the ischemic reperfused cells.
KeywordsGracilis Muscle Muscle Necrosis Skeletal Muscle Injury Leukocyte Endothelial Adhesion Scintillation Proximity Assay
Unable to display preview. Download preview PDF.
- 1.Adams J, Dhar A, Kikta M, et al. Role of platelet-activating factor in skeletal muscle ischemia reperfusion injury. Surg Forum:XLV; 395–397, 1994.Google Scholar
- 2.Adams J, Dhar A, Shukla S, Silver D. Effect of pentoxifylline on tissue injury and platelet-activating factor production during ischemia-reperfusion injury. JVS: 2I (5); 742–749, 1995.Google Scholar
- 7.Satewachin I, Iljin V, Schestakov V, et al. The use of pentoxifylline in a combined regimen for the prevention of re-thrombosis in major blood vessels. Pharmatherapeutica:2 Suppl 1; 109–117, 1978.Google Scholar
- 9.Schror K, Matzky R, Kahlen T, Darius H. The release of prostacyclin (PGI2) by pentoxyfylline from human and animal vascular tissue and its implications for vascular and antiplatelet activities. Thromb Haemost: 46; 272, 1981.Google Scholar