Abstract
Platelet-activating factor (PAF) is a bioactive phospholipid produced by activated inflammatory cells such as polymorphonuclear leukocytes, macrophages, platelets and endothelial cells1. Previous research showed that PAF in vivo, increases vascular permeability and infiltration of PMNs 2. Recent studies, however, have implicated PAF with virtually all inflammatory and immune responses 3. So, PAF influences either directly or indirectly many organ and tissue functions. In PMNs PAF induces chemotaxis, aggregation, adherence, lysosomal enzymes release and the production of leukotrienes and free radicals 4 , 5. In monocytes macrophages, low concentrations of PAF cause not only chemotaxis and aggregation but also potentiate, the IL-1, TNF and superoxide production 6,7. Also PAF induces inhibition of lymphocyte proliferation and IL-2 production was observed 8.
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References
Pinckard RN, Ludwing JC, McManus LM. (1988) In Platelet-activating factors; Editors Gallin Jl, Goldstein IM, Snyderman R.; pp. 139; Raven Press Ltd., N.Y.
Humphrey D.M., Hanahan D.J. and Pinckard R.N. (1982). Lab. Invest, 47: 227.
Braquet P. and Rola-Pleszcynski M. (1987) Immunology today, 8: 345.
Shaw J.O., Pinckard R.N., Ferrigni K.S., McManus L.M. and Hanahan D.J. (1981). J. Immun., 127: 1250.
Chilton F.H., O’Flaherty J.T., Walsh C.E., Thomas M.J., Wyklie R.L., DeChatelet L.R. and Waite B.M. (1982) J. Biol. Chem., 257: 5402.
Yasaka T., Boxer L.A. and Baehner R.L (1982). J. Immun., 128: 1939.
Pignol B., Henane S., Mencia-Huerta J.-M., Rola-Pleszynsky M. and Braquet P. (1987). Prostsglandins, 33: 931
Rola-Pleszcynsky M., Pignol B., Pouliot C. and Braquet O. (1987). Biochem. Biophys. Res. Commun., 142: 754.
Zimmerman GA, Prescott S.M., and McIntyre I.M. (1995) J. Nutr., 125: 16615.
Blank M.L., Lee T. C., Fitzegrald V. and Snyder F. (1981). J.Biol. Chem., 256: 175.
Gecno R.J. (1992). J. Periodontololy, 63: 338.
Pege R. (1991). J. Periodontol Res., 26: 230.
McManus LM., Marze B.T., and Schiess A.V. (1990). J. Peridont. Res., 25: 347.
Smal MA and Baldo BA (1991). Lipids, 26: 1144.
McDonnell HT (1993). J. Periodontology, 64: 1109.
Noguchi K., Morita I. and Murota S., (1989). Arch Oral Biol, 34: 37.
Bligh E. G., Dyer W. J. (1959) Can. J. Biochem. Physiol., 37: 911.
Andrikopoulos N. K., Demopoulos C. A., Siafaka-Kapadai A. (1986) J. Chromatogr., 363: 412.
Demopoulos C. A., Pinckard R. N., Hanahan D. J. (1979) J. Biol. Chem., 254: 9355.
Lazanas M., Demopoulos C. A., Tournis S., Koussissis S., Labrakis-Lazanas K., Tsarouxas X. (1988). Arch. Dermatol. Res., 280: 124.
Pinckard RN and Ludwing JC (1986) Fed Proc, 45: 856.
Loe H., Theilade E., Proglum-Jencen S. (1965). J. Periodontology, 36: 177.
Elstad M.R., Stafforini D.M., McLntyre T.M., Prescott S.M. and Zimmerman G.A. (1989). J.Biol. Chem., 264: 8467.
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Baltas, G., Kotsifaki, H., Antonopoulou, S., Kipioti, A., Demopoulos, C.A. (1996). Implication of PAF and Acetylhydrolase (PAF-AH) Activity in Periodontal Disease. In: Nigam, S., Kunkel, G., Prescott, S.M. (eds) Platelet-Activating Factor and Related Lipid Mediators 2. Advances in Experimental Medicine and Biology, vol 416. Springer, Boston, MA. https://doi.org/10.1007/978-1-4899-0179-8_23
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DOI: https://doi.org/10.1007/978-1-4899-0179-8_23
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