Implication of PAF and Acetylhydrolase (PAF-AH) Activity in Periodontal Disease

  • George Baltas
  • Helen Kotsifaki
  • Smaragdi Antonopoulou
  • Anthoula Kipioti
  • Constantinos A. Demopoulos
Part of the Advances in Experimental Medicine and Biology book series (AEMB, volume 416)

Abstract

Platelet-activating factor (PAF) is a bioactive phospholipid produced by activated inflammatory cells such as polymorphonuclear leukocytes, macrophages, platelets and endothelial cells1. Previous research showed that PAF in vivo, increases vascular permeability and infiltration of PMNs 2. Recent studies, however, have implicated PAF with virtually all inflammatory and immune responses 3. So, PAF influences either directly or indirectly many organ and tissue functions. In PMNs PAF induces chemotaxis, aggregation, adherence, lysosomal enzymes release and the production of leukotrienes and free radicals 4 , 5. In monocytes macrophages, low concentrations of PAF cause not only chemotaxis and aggregation but also potentiate, the IL-1, TNF and superoxide production 6,7. Also PAF induces inhibition of lymphocyte proliferation and IL-2 production was observed 8.

Keywords

Permeability HPLC Albumin Superoxide Prostaglandin 

Preview

Unable to display preview. Download preview PDF.

Unable to display preview. Download preview PDF.

References

  1. 1.
    Pinckard RN, Ludwing JC, McManus LM. (1988) In Platelet-activating factors; Editors Gallin Jl, Goldstein IM, Snyderman R.; pp. 139; Raven Press Ltd., N.Y.Google Scholar
  2. 2.
    Humphrey D.M., Hanahan D.J. and Pinckard R.N. (1982). Lab. Invest, 47: 227.PubMedGoogle Scholar
  3. 3.
    Braquet P. and Rola-Pleszcynski M. (1987) Immunology today, 8: 345.CrossRefGoogle Scholar
  4. 4.
    Shaw J.O., Pinckard R.N., Ferrigni K.S., McManus L.M. and Hanahan D.J. (1981). J. Immun., 127: 1250.PubMedGoogle Scholar
  5. 5.
    Chilton F.H., O’Flaherty J.T., Walsh C.E., Thomas M.J., Wyklie R.L., DeChatelet L.R. and Waite B.M. (1982) J. Biol. Chem., 257: 5402.Google Scholar
  6. 6.
    Yasaka T., Boxer L.A. and Baehner R.L (1982). J. Immun., 128: 1939.PubMedGoogle Scholar
  7. 7.
    Pignol B., Henane S., Mencia-Huerta J.-M., Rola-Pleszynsky M. and Braquet P. (1987). Prostsglandins, 33: 931Google Scholar
  8. 8.
    Rola-Pleszcynsky M., Pignol B., Pouliot C. and Braquet O. (1987). Biochem. Biophys. Res. Commun., 142: 754.Google Scholar
  9. 9.
    Zimmerman GA, Prescott S.M., and McIntyre I.M. (1995) J. Nutr., 125: 16615.Google Scholar
  10. 10.
    Blank M.L., Lee T. C., Fitzegrald V. and Snyder F. (1981). J.Biol. Chem., 256: 175.PubMedGoogle Scholar
  11. 11.
    Gecno R.J. (1992). J. Periodontololy, 63: 338.CrossRefGoogle Scholar
  12. 12.
    Pege R. (1991). J. Periodontol Res., 26: 230.CrossRefGoogle Scholar
  13. 13.
    McManus LM., Marze B.T., and Schiess A.V. (1990). J. Peridont. Res., 25: 347.Google Scholar
  14. 14.
    Smal MA and Baldo BA (1991). Lipids, 26: 1144.PubMedCrossRefGoogle Scholar
  15. 15.
    McDonnell HT (1993). J. Periodontology, 64: 1109.Google Scholar
  16. 16.
    Noguchi K., Morita I. and Murota S., (1989). Arch Oral Biol, 34: 37.PubMedCrossRefGoogle Scholar
  17. 17.
    Bligh E. G., Dyer W. J. (1959) Can. J. Biochem. Physiol., 37: 911.Google Scholar
  18. 18.
    Andrikopoulos N. K., Demopoulos C. A., Siafaka-Kapadai A. (1986) J. Chromatogr., 363: 412.PubMedCrossRefGoogle Scholar
  19. 19.
    Demopoulos C. A., Pinckard R. N., Hanahan D. J. (1979) J. Biol. Chem., 254: 9355.Google Scholar
  20. 20.
    Lazanas M., Demopoulos C. A., Tournis S., Koussissis S., Labrakis-Lazanas K., Tsarouxas X. (1988). Arch. Dermatol. Res., 280: 124.Google Scholar
  21. 21.
    Pinckard RN and Ludwing JC (1986) Fed Proc, 45: 856.Google Scholar
  22. 22.
    Loe H., Theilade E., Proglum-Jencen S. (1965). J. Periodontology, 36: 177.CrossRefGoogle Scholar
  23. 23.
    Elstad M.R., Stafforini D.M., McLntyre T.M., Prescott S.M. and Zimmerman G.A. (1989). J.Biol. Chem., 264: 8467.PubMedGoogle Scholar

Copyright information

© Springer Science+Business Media New York 1996

Authors and Affiliations

  • George Baltas
    • 1
  • Helen Kotsifaki
    • 2
  • Smaragdi Antonopoulou
    • 3
  • Anthoula Kipioti
    • 1
  • Constantinos A. Demopoulos
    • 3
  1. 1.Department of PeriodontologyUniversity of AthensAthensGreece
  2. 2.Department of PhysiologyUniversity of AthensAthensGreece
  3. 3.Department of ChemistryUniversity of AthensAthensGreece

Personalised recommendations