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Free Radical-Induced Oxidation of Glycerophosphocholine Lipids and Formation of Biologically Active Products

  • Robert C. Murphy
Part of the Advances in Experimental Medicine and Biology book series (AEMB, volume 416)

Abstract

Lipid mediators are a diverse family of biologically active compounds derived from phospholipids and are thought to play important roles both in physiological processes as well as pathophysiologic events. Perhaps the best studied class of lipid mediators are those derived from arachidonic acid, termed eicosanoids. Several enzymatic systems are known to be involved in their formation including prostaglandin H synthase which catalyzes the formation of cyclic endoperoxides, the direct precursor of prostaglandins, thromboxane, and prostacyclinl. Leukotrienes are formed from arachidonic acid by the enzyme 5-lipoxygenase which initially introduces oxygen into the arachidonic acid backbone2. Other biologically active eicosanoids are formed by 15-lipoxygenase3, 12-lipoxygenase4, and cytochrome P-4505. These enzymes use nonesterified arachidonic acid as substrate. Another important class of lipid mediator is platelet-activating factor which is derived from ether phospholipids and has acetate at the sn-2 position. The formation of the precursor lyso glycerophosphocholine as well as the subsequent acetylation process are enzymatically mediated’.

Keywords

Arachidonic Acid Lipid Mediator Carbon Centered Radical Ether Phospholipid Washed Rabbit Platelets26 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

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Copyright information

© Springer Science+Business Media New York 1996

Authors and Affiliations

  • Robert C. Murphy
    • 1
  1. 1.Division of Basic SciencesNational Jewish Center for Immunology and Respiratory MedicineDenverUSA

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