The Continuing Biochemical Challenge of PAF and Closely Related Lipid Mediators
The discovery that platelet-activating factor (PAF) was a biologically active phosphoglyceride expanded dramatically our concept of the role of the phospholipids in cellular events. In the past fifteen years of study on PAF and related lipid mediators, it is evident that on the one hand they shared many features in common with the more conventional phosphoglycerides, but on the other hand, the bio-active phosphoglycerides which appear to be restricted to those with choline or hydrogen in the polar head (base) group, had certain characteristics unique unto themselves. It is appropriate then to review the similarities in these two classes of compounds together with a discussion of their differences.
KeywordsPhosphatidic Acid Phosphatidic Acid Polar Head Potent Biological Activity Significant Biological Activity
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