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The Effect of Nutritional Supplementation on Stroke Mortality and Blood Pressure

Results from the Linxian Nutritional Intervention Trials
  • Steven D. Mark
  • Wen Wang
  • Joseph F. FraumeniJr.
  • Jun-Yao Li
  • Philip R. Taylor
  • Guo-Qing Wang
  • Wande Guo
  • Sanford M. Dawsey
  • Bing Li
  • William J. Blot

Abstract

Stroke disease is the second leading cause of death in Linxian, a county in north central China with one of the world’s highest rates of esophageal/gastric cardia cancer (1). The determinants of stroke in Linxian and other parts of China are not well known, but dietary factors, including low vitamin and mineral intake, may be involved. In the mid-1980’s two randomized trials were launched to test whether vitamin and mineral supplementation in this nutritionally deficient population would be effective in lowering cancer risks. Information on all deaths, including those from stroke, was ascertained. Measurements of blood pressure were taken prior to and at the end of the interventions. We have previously examined the effects of the interventions on stroke and hypertension (2, 3). In this paper we analyze the data from these trials in a uniform manner and evaluate the influence of the interventions and other pre-treatment factors such as sex and alcohol intake on stroke mortality and on hypertension.

Keywords

Homocysteine Level Stroke Mortality Sodium Selenate Diastolic Hypertension Baseline Risk Factor 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

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Copyright information

© Springer Science+Business Media New York 1996

Authors and Affiliations

  • Steven D. Mark
    • 1
  • Wen Wang
    • 1
  • Joseph F. FraumeniJr.
    • 1
  • Jun-Yao Li
    • 1
  • Philip R. Taylor
    • 1
  • Guo-Qing Wang
    • 1
  • Wande Guo
    • 1
  • Sanford M. Dawsey
    • 1
  • Bing Li
    • 1
  • William J. Blot
    • 1
  1. 1.National Cancer InstituteBethesdaUSA

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