Selenium and Kashin-Beck Disease
Kashin-Beck Disease (KBD) which hardly attracts attention in the west has been mainly found in remote and poor areas in China. The characteristics of the disease are short stature and deformed joints due to a focalised destruction of the chondrocytes of the articular cartilage and the growth zone (1). Although some factors have been found to be related to the prevalence of KBD, the etiology of the disease still is not clear since its distinct recognition around 1850. Shaanxi province with a population of 34 million is the most prevalent in P.R. China or in the world (2). 315252 cases were registered officially and over 4 million people were in the risk zone for KBD in Shaanxi province (3), where first reports and many intensive studies of selenium with KBD were carried out.
KeywordsGlutathione Peroxidase Short Stature Growth Zone Sodium Selenite Risk Zone
Unable to display preview. Download preview PDF.
- 1.Office for Controlling Endemic Dis., The Collections of Scientific Investigation on KBD in Yonshou county of Shaanxi Province, People’s Health Press, Beijing (1983).Google Scholar
- 2.WHO workshop meeting on KBD, draft report, May 28–29 (1992).Google Scholar
- 3.Li Jiyun, et al., Newsl. Endemic. Dis. 2, 22–28 (1979).Google Scholar
- 4.Shaanxi Provincial Health Dpt., Ann. Health Sta., Shaan xi Province (1984).Google Scholar
- 5.Li Jiyun, et al., J. Environ. Sci. 2, 91 (1982).Google Scholar
- 6.Wang Zhilun, et al., J. Xi’ an Med. Univ. 14, 31–32 (1993).Google Scholar
- 7.Wang Zhilun, et al, in Research on Regional Environment and Development, Wang H, ed., China Environmental Sciences Press, (1993).Google Scholar
- 8.Wang Zhilun, etal., J. Xi’ an Med. Univ. 14,7–9 (1993).Google Scholar
- 9.Wang Zhilun, et al., J. Xi’ an Med. Univ. 14, 22–27 (1993).Google Scholar
- 10.Peretz A, in Selenium in Medicine and Biology, Nève J and Favier A., ed. Walter de Gruyter. New York, pp 234–235(1988).Google Scholar
- 11.Peretz A. and Nève J. et al., Nutrition. 7, 215–221 (1991).Google Scholar