Relationships between Bone Mineral Density, Growth, and Aluminum in Healthy Former Premature Infant

  • D. Bouglé
  • F. Bureau
  • B. Guillois
  • R. Morello
  • J. F. Duhamel
  • J. P. Sabatier


The healthy adult is protected from aluminum (Al) accumulation by a low (< 1%) digestive absorption of ingested intake and by the renal excretion of the absorbed fraction (1). The main target organs for (Al) are bone, brain, liver and the hematopoietic system (1). In the premature infant (PT), tissue Al loading has been described at necropsy of critically ill subjects, due to IV feeding and renal failure (2–5). However, increased Al plasma levels have been described in healthy PT or fullterm infants (6–8). The functional relationship between such variations of serum Al and biological functions remains to be defined in the infant inasmuch as it has been claimed that Al blood levels might be of poor interest in adult subjects (1).


Bone Mineral Density Bone Mineralization Fullterm Infant Multiple Stepwise Regression Analysis Main Target Organ 
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  1. 1.
    A.C. Alfrey, in Trace elements in human and animal nutrition, 5th ed., vol.1, W. Mertz, ed., Academic Press Inc., Orlando, pp. 399–413 (1986).CrossRefGoogle Scholar
  2. 2.
    A.B. Sedman, G.L. Klein, R.J. Merritt, M.L. Miller, K.O. Weber, W.L. Gill, H.A. Anand. and C. Alfrey, N. Engl J. Med. 312, 1337–43 (1985).CrossRefGoogle Scholar
  3. 3.
    M. Freundlich, G. Zilleruelo, C. Abitbol, J. Strauss, M.C. Faugère and H.H. Malluche, Lancet 2, 527–9 (1985).CrossRefGoogle Scholar
  4. 4.
    W.W.K. Koo, L.A. Kaplan, R. Bendon, P. Succop, R.C. Tsang, J. Horn and J.J Steichen, J. Pediatr. 109, 877–83(1986).CrossRefGoogle Scholar
  5. 5.
    M.E.A. Bozynski, A.B. Sedman, R.A. Naglie and E.J. Wright, J.P.E.N. 13, 428–31 (1989).Google Scholar
  6. 6.
    D. Bouglé, F. Bureau, J. Voirin, D. Neuville and J.F. Duhamel, J. P. E. N 16, 167–9 (1992).Google Scholar
  7. 7.
    R. Litov, V.S. Sickles, G. Chan, M.A. Springer and A.C. Cordano, Pediatrics 84, 1105–7 (1989).Google Scholar
  8. 8.
    N.M. Hawkins, S. Coffey, M.S. Lawson and H.T. Delves, J. Pediatr.Gastroenterol. Nutr. 19, 377–81 (1994).CrossRefGoogle Scholar
  9. 9.
    W.W.K. Koo, S.K. Krug-Wispe, P. Succop, R. Bendon and L.A. Kaplan, Pediatrics 89, 877–81 (1992).Google Scholar
  10. 10.
    F.R. Greer, Annu. Rev. Nutr. 14, 169–85 (1994).CrossRefGoogle Scholar
  11. 11.
    S.A. Abrams, R.J. Schanler and C. Garza, J. Pediatr. 112, 956–60 (1988).CrossRefGoogle Scholar
  12. 12.
    G.M. Chan, J. Pediatr. 123, 439–43 (1993).CrossRefGoogle Scholar
  13. 13.
    S.W. Ryan, J. Truscott, M. Simpson and J. James, Acta Paediatr. 82, 518–21 (1993).CrossRefGoogle Scholar
  14. 14.
    R. Namgung, R.C. Tsang, B.L. Specker, R.I. Sierra and M.L. Ho, J. Pediatr. 122, 269–75 (1993).CrossRefGoogle Scholar
  15. 15.
    G.L. Klein and J.W. Coburn, Annu. Rev. Nutr. 14, 135–67 (1994).Google Scholar
  16. 16.
    L.D. Quarles, Am. J. Physiol. 258, E576–81 (1990).Google Scholar
  17. 17.
    J. Moon, A. Davison and B. Bandy, Can. Med. Assoc. J. 147, 1308–13 (1992).Google Scholar
  18. 18.
    P. Chappuis, J. Poupon, J. Arnaud, M.C. Jaudon and R. Zawislak, Am. J. Clin. Nutr. 54, 951–2 (1991).Google Scholar
  19. 19.
    W.W.K. Koo, L.A. Kaplan and S.K. Krug-Wispe, J.P.E.N. 12, 170–3 (1988).Google Scholar
  20. 20.
    D. Bouglé, P. Foucault, J. Voirin and J.F. Duhamel, Arch. Fr. Pédiatr. 46, 768 (1989).Google Scholar

Copyright information

© Springer Science+Business Media New York 1996

Authors and Affiliations

  • D. Bouglé
    • 1
  • F. Bureau
    • 1
  • B. Guillois
    • 1
  • R. Morello
    • 1
  • J. F. Duhamel
    • 1
  • J. P. Sabatier
    • 1
  1. 1.Laboratoire de Physiologie Digestive et Nutritionnelle, Laboratoire de Biochimie A, Service de Néonatologie, Laboratoire d’Informatique Médicale, Service de Pédiatrie A, Laboratoire des RadioisotopesCentre Hospitalo UniversitaireCaen CedexFrance

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