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Influence of Nutritional Status on Selenium Pharmacokinetics

  • V. Ducros
  • P. Faure
  • M. Ferry
  • F. Couzy
  • I. Biajoux
  • A. Favier

Abstract

Several studies of selenium (Se) retention in rats showed that whole body retention of 75Se tracer given as sodium selenite was considerably increased in Se-depleted rats (1–2). We were interested in studying the Se kinetics of a Se deficient human subject by using a safe stable isotope labeling. The deficiency was documented by plasma Se and plasma glutathione peroxidase (GSHPx) measurements. Results were compared with those obtained in subjects with normal Se status, of the same age, and sex, and living in the same area.

Keywords

Pool Size Sodium Selenite Mean Residence Time Elimination Rate Constant Atomic Absorption Spectro 
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Copyright information

© Springer Science+Business Media New York 1996

Authors and Affiliations

  • V. Ducros
    • 1
  • P. Faure
    • 1
  • M. Ferry
    • 2
  • F. Couzy
    • 3
  • I. Biajoux
    • 2
  • A. Favier
    • 1
  1. 1.Laboratoire de Biochimie CHôpital MichallonGrenoble cedex 9France
  2. 2.Service de GériatrieCentre HospitalierValence cedex 9France
  3. 3.Nestlé Research CentreLausanne 26Switzerland

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