Trace Elements and Bone Metabolism
The role of trace elements (TE) in bone has been mostly investigated for diagnostic procedures (isotopic scans, absorption test, fossil analysis) because they are bone-seekers that concentrate at the surface of bone. The presence of essential TE at physiological levels represents a reservoir (zinc, copper) while the presence of other elements which are environmental contaminants may be toxic for bone. Analysis of human skeletons from prehistoric to present time (1) revealed that TE concentrations vary with time and geographic situation. For example, bone lead concentration increased dramatically in Europe from prehistoric to middle-age, followed by a decrease until present period which seems in contradiction with the industry burst observed in our countries. The analysis of TE concentrations in bone for clinical or research purposes is a complicated task because reference data are lacking for “normal trace elements concentrations” in human bone biopsy. Very few authors (2) analysed human iliac crest bone for their bulk and trace elements in healthy and osteoporotic subjects.
KeywordsBone Resorption Zinc Sulfate Zinc Salt Menkes Disease Gallium Nitrate
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