The Influence of Lithium and Magnesium on Digestive Lesions Induced by Platelet Activating Factor in Rats
The Platelet Activating Factor (PAF) is a lipidic autacoid having the structure 1-O-alkyl-2-acetyl-sn-glyceryl-3′-phosphorylcholine and is widely spread in a great variety of human and animal tissues (1–3). Numerous physiological and pathological involvements of PAF are known. Several authors (1,4–6) have shown that PAF produces ulceration and hemorrhages in the digestive tract. The ulcerogenic effect of PAF was observed after intravenous or topical administration at the gastric mucosa level. The mechanisms through which PAF exerts its lesional activity at the level of gastric mucosa are very complex and not completely identified. Among mechanisms proposed to explain the ulcerogenic effects of PAF are: damages of microcirculation of gastric mucosa (7), increase of free radical production (8), increase of acid secretion, formation of platelets microaggregates, increase of aggregation of neutrophils and release of lysosomal enzymes (9). In this paper, the effects of magnesium, calcium and lithium on the lesions produced by intravenous administration of PAF in rats were investigated.
KeywordsGastric Mucosa Platelet Activate Factor Gastric Lesion Lesional Score Gastric Mucosa Lesion
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