Relationship between Antioxidant Enzyme Activities and Cardiac Susceptibility to Ischaemia and Reperfusion during Aging in Rats
Numerous studies have shown that ischaemic damage and the so called reperfusion syndrome of the myocardium are, at least in part, associated to a burst of oxygen-derived free radicals (1). The involvement of reactive oxygen species (ROS) in post-ischaemic contractile dysfunction is supported by several studies underlying the benefit of the use of antioxidant catalytic agents such as Superoxide dismutase and/or catalase during experimental cardiac reperfusion (2,3). Endogenous catalytic ROS scavengers, namely Superoxide dismutase (SOD), catalase (CAT) glutathione peroxidase (GPx) and glutathione reductase (GRx) play key roles in the cellular defence systems against ROS under pathophysiological conditions (3–5). The myocardial activity of these enzymes is therefore determinant to protect the heart during post-ischaemic reperfusion. It is now well established that ageing is associated to an increase in cardiac susceptibility to ischaemia (6) and reperfusion (7) in rats. The present study was designed to define the relationship between the endogenous antioxidant status and cardiac susceptibility to ischaemia and reperfusion during ageing.
KeywordsGlutathione Peroxidase Glutathione Reductase Antioxidant Enzyme Activity Glutathione Peroxidase Activity Myocardial Activity
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