Usefulness of Plasma Zinc Protoporphyrin (ZPP) Dosage in the Assessment of Iron Status in the Iron Deficient Rat
Iron is a mineral frequently deficient in diets of industrialised countries (1). Assessment of iron status still requires the determination of several parameters of iron metabolism (2). Heme is formed in the developing erythrocytes by insertion of iron into a formed porphyrin ring. In the event of insufficient iron supply or impaired iron utilisation, zinc is substituted for iron into porphyrin IX. The Zinc Protoporphyrin (ZPP) formed in the chelation process is stable and remains in the red cell for its 120 days of life span. Because ZPP concentration increases in iron deficiency, its dosage has been proposed as an early index of iron deficiency using haematofluorometry (3).
KeywordsIron Deficiency Iron Intake Iron Status Iron Metabolism Liver Iron Concentration
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- 1.S. Hercberg, P. Preziosi, P. Galan, in Les oligoéléments en médecine et en biologie, ed., SFERETE Tech & Doc Lavoisier, pp. 233-346 (1991).Google Scholar
- 2.M. Worwood, in Iron metabolism in healthy and disease, ed., W Saunders Company Ltd, London, 14, 450–463 (1994).Google Scholar
- 3.R.F. Labbe et al, Clin. Chem. 25, 87–92 (1979).Google Scholar
- 5.J. Hastka, J.J. Lasserre, A. Shwarzbeck, and R. Hehlmann, Clin. Chem. 40, 768–773 (1994).Google Scholar
- 6.E.E. Langer, R.G. Haining, R.F. Labbe, P. Jacobs, E.F. Crosby, and C.A. Finch, Blood 40, 112–129 (1972).Google Scholar
- 7.J.R. Hunt, C.A. Zito, J. Erjavec, and L.K. Johnson, Am. J. Clin. Nutr. 59, 413–8 (1994).Google Scholar