Copper-Histidine and -NSAID Complexes in Fenton Chemistry

Preliminary Results
  • S. Gaubert
  • L. Lambs
  • G. Berthon


At first sight, the behaviour of copper with respect to inflammation may seem paradoxical. On the one hand, copper exerts antiinflammatory activity. It has long been known that copper complexes of non-steroidal antiinflammatory drugs (NSAIDs) are more effective than parent molecules and that substances inactive by themselves may become antiinflammatory when administered with copper. It has been suggested from this that the active metabolites of NSAIDs are the complexes they form with endogenous copper (1). On the other hand, it is no longer debated that copper, like iron, can act as a catalyst in Fenton-type reactions to produce hydroxyl radicals (2) which are key mediators of the inflammatory process (3).


Scavenge Activity Copper Complex Anthranilic Acid Produce Hydroxyl Radical Speciation Calculation 
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Copyright information

© Springer Science+Business Media New York 1996

Authors and Affiliations

  • S. Gaubert
    • 1
  • L. Lambs
    • 1
  • G. Berthon
    • 1
  1. 1.INSERM U305Equipe “Bioréactifs: Spéciation et Biodisponibilité”ToulouseFrance

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