Insertion/Deletion (I/D) Polymorphism in the Angiotensin Converting Enzyme (ACE) Gene

  • Kåre Berg
Part of the NATO ASI Series book series (NSSA, volume 294)


The insertion/deletion (I/D) polymorphism at the locus for the angiotensin I converting enzyme (ACE) has been the focus of considerable interest since the report by Cambien and his co-workers (Cambien et al., 1992) of association between the D allele and coronary heart disease (CHD), particularly in CHD patients without classical risk factors. In the following, this observation by Cambien’s group will be compared with observations in our group and with some of the studies in the literature.


Angiotensin Convert Enzyme Coronary Heart Disease Risk Coronary Heart Disease Patient Angiotensin Convert Enzyme Activity Deletion Polymorphism 
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Copyright information

© Springer Science+Business Media New York 1998

Authors and Affiliations

  • Kåre Berg
    • 1
    • 2
  1. 1.Institute of Medical GeneticsUniversity of OsloOsloNorway
  2. 2.Department of Medical GeneticsUllevaal University HospitalOsloNorway

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