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Increased Nitric Oxide Production in Heart Failure and Correlation with Functional Severity

  • David S. Winlaw
  • Phillip M. Sprati
  • Peter S. Macdonald
Part of the NATO ASI Series book series (NSSA, volume 294)

Abstract

The role of nitric oxide (NO) in heart failure is unknown. Studies of isolated blood vessels from patients with heart failure demonstrate impaired NO-dependent relaxation to acetylcholine. On the other hand, endomyocardial biopsy specimens from patients with dilated cardiomyopathy show increased activity of the inducible isoform of nitric oxide synthase (iNOS). Plasma levels of TNF-α, an activator of iNOS, are increased in heart failure, and TNF-α has been shown to have negative inotropic effects in hamster papillary muscle through an NO-dependent mechanism.

Keywords

Heart Failure Nitric Oxide Nitric Oxide Nitric Oxide Production Negative Inotropic Effect 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

Copyright information

© Springer Science+Business Media New York 1998

Authors and Affiliations

  • David S. Winlaw
    • 1
  • Phillip M. Sprati
    • 1
  • Peter S. Macdonald
    • 1
  1. 1.St. Vincent’s HospitalSydneyAustralia

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