Complement Inhibitor Therapeutics and Lung Injury

  • Una S. Ryan
Part of the NATO ASI Series book series (NSSA, volume 294)


Lung injury from any cause can have severe clinical outcomes. The Adult Respiratory Distress Syndrome (ARDS) was defined as a clinical entity in 1967.1 It is generally recognized as acute respiratory failure characterized by relatively normal cardiac function, an increase in vascular permeability leading to pulmonary edema manifested by diffuse pulmonary infiltrates on the chest X-ray and by a major oxygenation defect.2 Precipitating insults include severe sepsis, diffuse pneumonia, pancreatitis, multiple trauma, aspiration, near-drowning, burns, shock, hypotension, and coagulopathy. ARDS is a major contributor to the morbidity and mortality of patients in intensive care units with 30-day mortality rates varying from 55 to 65%.1–4 Current estimates are that more than 100,000 patients per year in the U.S. develop ARDS.5


Lung Injury Complement Activation Constitutive Function Complement Inhibitor Terminal Complex 


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Copyright information

© Springer Science+Business Media New York 1998

Authors and Affiliations

  • Una S. Ryan
    • 1
  1. 1.T Cell Sciences, Inc.NeedhamUSA

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