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Antitumor Activity of IL-12 in a Mouse Opportunistic Vascular Tumor: Role of Immunocompetent Cells and Cytokines

  • F. Fioretti
  • Q. G. Dong
  • M. Fusco
  • A. Vecchi
  • A. Mantovani
Part of the NATO ASI Series book series (NSSA, volume 294)

Abstract

IL-12 has been reported to have antitumoral activity in different mouse tumors. In this study IL-12 was tested on the in vivo growth of H5V cells, a tumor line obtained by polyoma middle T (PmT) infection of mouse endothelial cells (Garlanda et al., P.N.A.S., 91:7291, 1994). H5V injection in syngeneic hosts causes vascular tumors that may represent an experimental model for human opportunistic vascular tumors. T lymphocytes, mainly CD8, and Th1 cytokines have been shown to play a major role in the in vivo resistance to H5V to H5V tumor; IFNγ and TGFb1 display antitumoral activity, mainly in immunocompetent hosts.

Keywords

Antitumoral Activity Treated Animal Vascular Tumor Mouse Tumor Tumor Line 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

Copyright information

© Springer Science+Business Media New York 1998

Authors and Affiliations

  • F. Fioretti
    • 1
  • Q. G. Dong
    • 1
  • M. Fusco
    • 1
  • A. Vecchi
    • 1
  • A. Mantovani
    • 1
  1. 1.Instituto di Ricerche Farmacologiche “Mario Negri”MilanItaly

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