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Tumor Necrosis Factor α Induces PAF-Dependent Angiogenesis

  • A. De Martino
  • G. Montrucchio
  • E. Lupia
  • E. Battaglia
  • F. Bussolino
  • G. Camussis
Part of the NATO ASI Series book series (NSSA, volume 294)

Abstract

The in vivo angiogenic effect of tumor necrosis factor (TNF) α is considered due to the production of secondary mediators, as it is in vitro a potent inhibitor of endothelial cell growth (1). Since TNF-α stimulates the synthesis of platelet-activating factor (PAF), a phospholipid mediator of inflammation and septic shock, by monocytes and endothelial cells (EC) (2), we investigated the possible involvement of PAF in the angiogenetic effect of TNF-α.

Keywords

Endothelial Cell Tumor Necrosis Factor Septic Shock Endothelial Cell Growth Angiogenic Effect 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

References

  1. 1.
    Frater-Schroder M., Risau W., Hallaman R., et al. (1987) Proc. Natl. Acad. Sci. USA 84:5227.CrossRefGoogle Scholar
  2. 2.
    Camussi G., Bussolino F., Salvidio G., and Baglioni C. (1987) J. Exp. Med. 166:1390.PubMedCrossRefGoogle Scholar
  3. 3.
    Passaniti A., Taylor R.M., Pili R., et al. (1992) Lab Invest. 67:519.PubMedGoogle Scholar

Copyright information

© Springer Science+Business Media New York 1998

Authors and Affiliations

  • A. De Martino
    • 1
  • G. Montrucchio
    • 1
  • E. Lupia
    • 1
  • E. Battaglia
    • 1
  • F. Bussolino
    • 2
  • G. Camussis
    • 3
  1. 1.Department of Clinical PhysiopathologyUniversity of TorinoItaly
  2. 2.Department of Genetics Biology and Medical ChemistryUniversity of TorinoItaly
  3. 3.Division of Nephrology and MicrobiologyUniversity of PaviaItaly

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