Effects of Endotoxin on Endothelium-Dependent and -Independent Responses in the Isolated Rat Heart

  • Richard G. Bogle
  • Patrick Vallance
Part of the NATO ASI Series book series (NSSA, volume 294)

Abstract

Endotoxin is thought to be the initiator of a cascade of responses resulting in septic shock [1]. Its effects are mediated via cytokine-induction that in turn increases expression of enzymes producing pro-inflammatory mediators. It is clear that induction of nitric oxide synthase in the vasculature is important in producing the hypotension and smooth muscle hypo-responsiveness to vasoconstrictors associated with septic shock [2]. Less is known about the effects of endotoxin on endotheliumdependent responses. The aim of this study was to determine the effects of endotoxin on endothelial responses in the microvasculature of the heart.

Keywords

Electrophoresis Nitrite Dexamethasone Carnitine Bradykinin 

References

  1. 1.
    Bayston, K.F. & Cohen, J. (1990). Bacterial endotoxin and current concepts in the diagnosis and treatment of endotoxaemia. J. Med. Microbiol., 31, 73–83.PubMedCrossRefGoogle Scholar
  2. 2.
    Bogle, R.G. & Vallance, P. (1996). Regulation of vascular smooth muscle tone in sepsis. In: Pharmacology of Vascular Smooth Muscle. Ed. Garland, C. & Allen, J. Oxford University Press.Google Scholar
  3. 3.
    Criddle, D.N., Dewar, G.H., Radniknam, M., Wathey, W.B. & Woodward, B. (1991). The synthesis and structure-activity relationships of some long chain acyl carnitine esters on the coronary circulation of the rat isolated heart. J. Pharm. Pharmacol., 43, 636–639.PubMedCrossRefGoogle Scholar
  4. 4.
    Leone, A.M., Francis, P.L., Rhodes, P., Furst, V. & Moncada, S. (1995). A rapid and simple method for the measurement of nitrite and nitrate in plasma by high performance capillary electrophoresis. Biochem. Biophys. Res. Commun., 200, 951–957.CrossRefGoogle Scholar

Copyright information

© Springer Science+Business Media New York 1998

Authors and Affiliations

  • Richard G. Bogle
    • 1
  • Patrick Vallance
    • 2
  1. 1.Clinical Pharmacology Unit, Department of Pharmacology and Clinical PharmacologySt. George’s Hospital Medical SchoolLondonUK
  2. 2.Centre for Clinical Pharmacology, Cruciform Project for Strategic Medical ResearchUniversity College London, The Rayne InstituteLondonUK

Personalised recommendations