Effects of Endotoxin on Endothelium-Dependent and -Independent Responses in the Isolated Rat Heart
Endotoxin is thought to be the initiator of a cascade of responses resulting in septic shock . Its effects are mediated via cytokine-induction that in turn increases expression of enzymes producing pro-inflammatory mediators. It is clear that induction of nitric oxide synthase in the vasculature is important in producing the hypotension and smooth muscle hypo-responsiveness to vasoconstrictors associated with septic shock . Less is known about the effects of endotoxin on endotheliumdependent responses. The aim of this study was to determine the effects of endotoxin on endothelial responses in the microvasculature of the heart.
KeywordsSeptic Shock Krebs Solution Coronary Perfusion Pressure Endothelial Response Acyl Carnitine
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