Abstract
Polymeric injectable carriers, able to deliver drugs or other compounds to specific sites of action for a prolonged time, represent a potential therapeutic approach for several diseases. However, therapeutic activity is compromised by particle recognition by the macrophages of the mononuclear phagocyte system (MPS) and their elimination within seconds, or minutes after intravenous injection. Blood proteins (opsonins) adsorb onto the particles surface, making them recognizable to the macrophages of the MPS.
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Peracchia, M.T. et al. (1998). Development of Novel Technologies for the Synthesis of Biodegradable Pegylated Nanoparticles. In: Gregoriadis, G., McCormack, B. (eds) Targeting of Drugs 6. NATO ASI Series, vol 300. Springer, Boston, MA. https://doi.org/10.1007/978-1-4899-0127-9_20
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DOI: https://doi.org/10.1007/978-1-4899-0127-9_20
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