Polysialic Acids: Potential for Long Circulating Drug, Protein, Liposome and Other Microparticle Constructs
Optimal use of drugs often requires their extended presence within the vascular system or in extravascular areas (Gregoriadis et al, 1994). For instance, some antibiotics and cytostatics and a variety of peptides and proteins including hormones, cytokines, enzymes, antibodies and haemoglobin (as a blood surrogate) are excreted or removed from the circulation by tissues rapidly and before therapeutic concentrations in target areas can be achieved. Such drugs could be more effective, less toxic and also used in smaller quantities if their presence in the blood circulation (and hence interaction with corresponding receptors or substrates intravascularly or extravascularly) could be prolonged (Lee et al., 1995). In the same way, prolonged circulation of drug delivery systems such as liposomes (Gregoriadis, 1995), other colloidal systems (Davis et al., 1984) and polymers (Domb et al., 1997) would facilitate targeting of drugs to cells other than those (e.g. the reticuloendothelial system; RES) by which many of these systems are normally intercepted (Gregoriadis, 1995; Lee et al., 1995)
KeywordsAmmonium Sulphate Capsular Polysaccharide Neisseria Meningitidis Polysialic Acid Asparaginase Activity
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