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Diagnostic and Therapeutic Targeting of Infectious and Inflammatory Diseases Using Sterically Stabilized Liposomes

  • G. Storm
  • I. A. J. M. Bakker-Woudenberg
  • R. M. Schiffelers
  • W. J. G. Oyen
  • D. J. A. Crommelin
  • F. H. M. Corstens
  • O. C. Boerman
Chapter
Part of the NATO ASI Series book series (NSSA, volume 300)

Abstract

The ability to selectively target molecules to specific sites within the body has been one of the most coveted goals in experimental and clinical therapeutics. The performance of many diagnostic and therapeutic agents, both existing and promising new ones (like biomacromolecules such as proteins and DNA), would benefit greatly from targeted delivery strategies. Perhaps the major reason for the resurgence of interest in liposomal delivery systems for targeted delivery relates to the development of long-circulating “stealth” liposomes. As discussed elsewhere in this volume, the principal results have been obtained by modification of the liposomal surface through the use of the hydrophilic polymer polyethylene glycol conjugated to the lipid phosphatidylethanolamine (PEG-PE). This contribution will discuss the utility of PEG-coated liposomes (often referred to as sterically stabilized liposomes) for the imaging and therapy of infectious and inflammatory diseases.

Keywords

Post Injection Mononuclear Phagocyte System Inflammatory Focus Imaging Infection Inflammation Imaging 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

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References

  1. Baba, A.A., McKillop, J.H., Cuthbert, G.F., Neilson, W., Gray, H.W., and Anderson, J.R., 1990, 111Indium leucocyte scintigraphy in abdominal sepsis: do the results affect management?, Eur. J. Nucl. Med. 16: 307.PubMedCrossRefGoogle Scholar
  2. Bakker-Woudenberg, I.A.J.M., Lokerse, A.F., ten Kate, M.T., and Storm, G., 1992, Enhanced localization of liposomes with prolonged blood circulation time in infected lung tissue, Biochim. Biophys. Acta 1138: 318.PubMedCrossRefGoogle Scholar
  3. Bakker-Woudenberg, I.A.J.M., Lokerse, A.F., ten Kate, M.T., Mouton, J.W., Woodle, M.C., and Storm, G., 1993, Liposomes with prolonged blood circulation and selective localization in Klebsiella Pneumoniae-infected lung tissue, J. Infect. Dis. 168: 164.PubMedCrossRefGoogle Scholar
  4. Bakker-Woudenberg, I.A.J.M., ten Kate, M.T., Stearne-Cullen, L.E.T., and Woodle, M.C., 1995, Efficacy of gentamicin or ceftazidime entrapped in liposomes with prolonged blood circulation and enhanced localization in Klebsiellapneumoniae-infectcd lung tissue, J. Infect. Dis. 171:938.PubMedCrossRefGoogle Scholar
  5. Blok, D., van Ogtrop, M., Arndt, J.W., Camps, J.A.J., Feitsma, R.I.J., Goedemans, W., and Pauwels, E.K.J., 1990, Detection of inflammatory lesions with radiolabelled immunoglobulins, Eur. J. Nucl. Med. 16: 303.PubMedCrossRefGoogle Scholar
  6. Buscombe, J.R., Lui, D., Ensing, G., de Jong, R., and Ell, P.J., 1990, 99mTc-human immunoglobulin (HIG) — first results of a new agent for the localization of infection and inflammation, Eur. J. Nucl. Med. 16: 649.PubMedCrossRefGoogle Scholar
  7. Boerman, O.C., Storm, G., Oyen, W.J.G., van Bloois, L., van der Meer, J.W.M., Ciaessens, R.A.M.J., Crommelin, D.J.A., and Corstens, F.H.M., 1995, Sterically stabilized liposomes labeled with indium-111 to image focal infection in rats, J. Nucl. Med. 36: 1639.PubMedGoogle Scholar
  8. Boerman, O.C., Oyen, W.J.G., van Bloois, L., van der Meer, J.W.M., Koenders, E.B., Corstens, F.H.M., and Storm, G., 1997, Optimization of 99mTc-labeled PEG-liposomes to image focal infection: effects of particle size and circulation time, J. Nucl. Med. 38: 489.PubMedGoogle Scholar
  9. Boerman, O.C., Oyen, W.J.G., Corstens, F.H.M., and Storm, G., 1997, Sterically stabilized liposomes to image infection and inflammation, in: Long-Circulating Liposomes: Old Drugs, New Therapeutics, M.C. Woodle and G. Storm, eds., Landes Bioscience Pub., Springer, Austin, Texas.Google Scholar
  10. Buscombe, J.R., Lui, D., Ensing, G., de Jong, R., and Ell, P.J., 1990, 99mTc-human immunoglobulin (HIG) — first results of a new agent for the localization of infection and inflammation, Eur. J. Nucl. Med. 16: 649.PubMedCrossRefGoogle Scholar
  11. Bone, R.C., 1993, Gram-negative sepsis: a dilemma of modern medicine, Clin. Microbiol. Rev. 6:57.PubMedGoogle Scholar
  12. Claessens, R.A.M.J., Boerman, O.C., Koenders, E.B., Oyen, W.J.G., van der Meer, J.W.M., and Corstens, F.H.M., 1996, Technetium-99m labelled hydrazinonicotinamido human non-specific polyclonal immunoglobulin G for detection of infectious foci: a comparison with two other technetium-labelled immunoglobulin preparations, Eur. J. Nucl. Med. 23, 414.PubMedCrossRefGoogle Scholar
  13. Coleman, R.E., 1982, Radiolabeled leukocytes, Nuclear Medicine Annual, L.M. Freeman and H.S. Weissmann, eds., New York: Raven Press, p. 119.Google Scholar
  14. Ellner, J.J., Hinman, A.R., Dooley, S.W., Fischl, M.A., Sepkowitz, K.A., Goldberger, M.J., Shinnick, T.M., Iseman, M.D., and Jacobs, W.R., 1993, Tuberculosis symposium: emerging problems and promise, J. Infect. Dis. 168:537.PubMedCrossRefGoogle Scholar
  15. Froelich, J.W., and Swanson, D., 1984, Imaging of inflammatory processes with labeled cells, Semin. Nucl. Med. 14:128.PubMedCrossRefGoogle Scholar
  16. Ito, Y., Okuyama, S., Awano, T., Takahashi, K., Sato, T., and Kanno, I. 1971, Diagnostic evaluation of Ga-67 scanning of lung cancer and other diseases, Radiology 101: 355.PubMedGoogle Scholar
  17. Lavender, J.P., Lowe, J., Barker, J.R., Burn, J.I., and Chaudri, M.A., 1971, Gallium-67 citrate scanning in neoplastic and inflammatory lesions, Brit. J. Radiol 44: 361.PubMedCrossRefGoogle Scholar
  18. McAfee, J.G., and Thakur, M.L., 1976, Survey of radioactive agents for the in vitro labeling of phagocytic leucocytes. I. Soluble agents. II. Particles, J. Nucl. Med. 17: 480.PubMedGoogle Scholar
  19. Oyen, W.J.G., Claessens, R.A.M.J, van der Meer, J.W.M., and Corstens, F.H.M., 1991, Detection of subacute infectious foci with indium-111-labeled autologous leukocytes and indium-111-labeled human nonspecific immunoglobulin G: a prospective comparative study, J. Nucl. Med. 32: 1854.PubMedGoogle Scholar
  20. Oyen, W.J.G., Claessens, R.A.M.J., van der Meer, J.W.M., Rubin, R.H., Strauss, H.W., and Corstens, F.H.M., 1992a, 111Indium-labeled human nonspecificimmunoglobulin G: A new radiopharmaceutical for imaging infectious and inflammatory foci, Clin. Inf. Dis. 14: 1110.CrossRefGoogle Scholar
  21. Oyen, W.J.G., van Horn, J.R., Claessens, R.A.M.J., Slooff, T.J.J.H., van der Meer, J.W.M., and Corstens, F.H.M., 1992b, Diagnosis of bone, joint and joint prothesis infections with indium-111-labeled nonspecific human immunoglobulin G scintigraphy, Radiology 182: 195.PubMedGoogle Scholar
  22. Oyen, W.J.G., Claessens, R.A.M.J., Raemaekers, J.M.M., de Pauw, B.E., van der Meer, J.W.M., and Corstens, F.H.M., 1992c, Diagnosing infection in febrile granulocytopenic patients with indium-111-labeled human IgG, J. Clin. Oncol. 10: 61.PubMedGoogle Scholar
  23. Oyen, W.J.G., Netten, P.M., Lemmen, A.M., Claessens, R.A.M.J., Lutterman, J.A., van der Vliet, J.A., Goris, J.A., van der Meer, J.W.M., and Corstens, F.H.M., 1992d, Evaluation of infectious diabetic foot complications with Indium-111-labeled human nonspecific immunoglobulin G, J. Nucl. Med. 33: 1330.PubMedGoogle Scholar
  24. Oyen, W.J.G., Boerman, O.C., Storm, G., van Bloois, L., Koenders, E.B., Claessens, R.A.M.J., Perenboom, R.M., Crommelin, D.J.A., van der Meer, J.W.M., and Corstens, F.H.M., 1996, Detecting infection and inflammation with Tc99m-labeled Stealth liposomes, J. Nucl Med. 37: 1392.PubMedGoogle Scholar
  25. Oyen, W.J.G., Boerman, O.C., Storm, G., van Bloois, L., Koenders, E.B., Crommelin, D.J.A., van der Meer, J.W.M., and Corstens, F.H.M., 1996, Labeled StealthR liposomes in experimental infection: an alternative to leukocyte scintigraphy?, Nuclear Med. Commun. 17; 742.CrossRefGoogle Scholar
  26. Peters, A.M., Danpure, HJ., Osman, S., Hawker, R.J., Henderson, B.L., Hodgson, HJ., Kelly, J.D., Neirinckx, R.D., and Lavender, J.P., 1986, Clinical experience with Tc-99m-HMPAO for labelling leucocytes and imaging infection, Lancet 2: 946.PubMedCrossRefGoogle Scholar
  27. Phillips, W.T., Rudolf, A.S., Goins, B., Timmons, J.H., Klipper, R., and Blumhardt, R., 1992, A simple method for producing a technetium-99m-labeled liposome which is stable in vivo, Nucl. Med. Biol 19: 539.Google Scholar
  28. Rubin, R.H.H, Fischman, A. J., Callahan, R.J., Khaw, B.A., Keech, F., Ahmad, M., Wilkinson, R., and Strauss, H.W., 1989, In-111-labeled nonspecific immunoglobulin scanning in the detection of focal infection, N. Eng. J. Med. 321:935.CrossRefGoogle Scholar
  29. Storm, G., Belliot, S.O., Daemen, T., and Lasic, D.D., 1995, Surface modification of nanoparticles to oppose uptake by the mononuclear phagocyte system, Adv. Drug Delivery Rev. 17:31.CrossRefGoogle Scholar

Copyright information

© Springer Science+Business Media New York 1998

Authors and Affiliations

  • G. Storm
    • 1
  • I. A. J. M. Bakker-Woudenberg
    • 2
  • R. M. Schiffelers
    • 1
    • 2
  • W. J. G. Oyen
    • 3
  • D. J. A. Crommelin
    • 1
  • F. H. M. Corstens
    • 3
  • O. C. Boerman
    • 3
  1. 1.Dept of Pharmaceutics, Utrecht Inst. for Pharmaceutical SciencesUtrecht UniversityUtrechtThe Netherlands
  2. 2.Dept of Clinical MicrobiologyErasmus UniversityRotterdamThe Netherlands
  3. 3.Dept of Nuclear MedicineUniversity Hospital NijmegenThe Netherlands

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