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Taurine 3 pp 431-439 | Cite as

Unique Pharmacological Interactions of Taurine and Chelerythrine in the Retina

  • Julius D. Militante
  • John B. Lombardini
Part of the Advances in Experimental Medicine and Biology book series (AEMB, volume 442)

Abstract

The effects of taurine and chelerythrine (CHT) on ATP-dependent calcium uptake and the phosphorylation of the ~20 kDa phosphoprotein in the retina were compared. In the absence of the CHT, taurine stimulated ATP-dependent calcium uptake and attenuated the phosphorylation of the ~20 kDa phosphoprotein. On the other hand, CHT produced the opposite results in the absence of taurine. When the two agents were used simultaneously, it was found that CHT non-competitively inhibited the action of taurine to stimulate calcium uptake, while taurine non-competitively inhibited the action of CHT to stimulate the phosphorylation of the ~20 kDa phosphoprotein. The data present an unusual pharmacological mechanism for controlling the signal transduction pathway involving the two distinct cellular processes being studied. Given the unique data, a control system is proposed in which the function of the ~20 kDa phosphoprotein is linked to the stimulation of ATP-dependent calcium uptake.

Keywords

Calcium Uptake Okadaic Acid Taurine Depletion Chelerythrine Chloride Benzophenanthridine Alkaloid 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

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Copyright information

© Springer Science+Business Media New York 1998

Authors and Affiliations

  • Julius D. Militante
    • 1
  • John B. Lombardini
    • 1
    • 2
  1. 1.Departments of PharmacologyTexas Tech University Health Sciences CenterLubbockUSA
  2. 2.Ophthalmology & Visual SciencesTexas Tech University Health Sciences CenterLubbockUSA

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