Taurine 3 pp 397-403 | Cite as

Effect of Taurine on Human Fetal Neuron Cells: Proliferation and Differentiation

  • Xue-Cun Chen
  • Zhi-Ling Pan
  • Dong-Sheng Liu
  • Xiaobin Han
Part of the Advances in Experimental Medicine and Biology book series (AEMB, volume 442)


The purpose of this study was to investigate the effect of taurine on human fetal brain neuron cell proliferation and differentiation using a glial-free, pure cerebral neuronal culture grown in a serum-free environment. We found that taurine was necessary for neuronal survival and neurite extension. Taurine, on the other hand, has a trophic effect on the human fetal brain cell, promoting both proliferation and differentiation. Results showed that DNA synthesis of the neurons was increased in a dose-dependent manner when neurons were cultured in the medium containing taurine (100–6400 μM). The protein content of neuronal cells was also significantly increased in the neurons treated with taurine as compared to the control. At day 15, the expression of neuron-specific enolase (NSE) was only detected in the neurons cultured in the medium containing taurine. These results establish taurine as a putative human fetal brain neurontrophic factor in the process of human brain development.


Neurite Outgrowth Neurite Extension Human Neuron Human Fetal Brain Define Chemical Medium 
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Copyright information

© Springer Science+Business Media New York 1998

Authors and Affiliations

  • Xue-Cun Chen
    • 1
  • Zhi-Ling Pan
    • 1
  • Dong-Sheng Liu
    • 1
  • Xiaobin Han
    • 2
  1. 1.Institute of Nutrition and Food HygieneCAPMBeijingChina
  2. 2.Department of PediatricsUniversity of TennesseeMemphisUSA

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