Taurine 3 pp 397-403 | Cite as

Effect of Taurine on Human Fetal Neuron Cells: Proliferation and Differentiation

  • Xue-Cun Chen
  • Zhi-Ling Pan
  • Dong-Sheng Liu
  • Xiaobin Han
Part of the Advances in Experimental Medicine and Biology book series (AEMB, volume 442)


The purpose of this study was to investigate the effect of taurine on human fetal brain neuron cell proliferation and differentiation using a glial-free, pure cerebral neuronal culture grown in a serum-free environment. We found that taurine was necessary for neuronal survival and neurite extension. Taurine, on the other hand, has a trophic effect on the human fetal brain cell, promoting both proliferation and differentiation. Results showed that DNA synthesis of the neurons was increased in a dose-dependent manner when neurons were cultured in the medium containing taurine (100–6400 μM). The protein content of neuronal cells was also significantly increased in the neurons treated with taurine as compared to the control. At day 15, the expression of neuron-specific enolase (NSE) was only detected in the neurons cultured in the medium containing taurine. These results establish taurine as a putative human fetal brain neurontrophic factor in the process of human brain development.


Neurite Outgrowth Neurite Extension Human Neuron Human Fetal Brain Define Chemical Medium 


Unable to display preview. Download preview PDF.

Unable to display preview. Download preview PDF.


  1. 1.
    Bock, E., 1978, Nervous system specific proteins, J. Neurochem., 30:7–14.PubMedCrossRefGoogle Scholar
  2. 2.
    Gaull, G.E., 1982, Taurine in the nutrition of human infant, Acta Paediatr. Scand. Suppl., 296:38–47.PubMedCrossRefGoogle Scholar
  3. 3.
    Gaull, G.E., Wright, C.E., and Tallan, H.H. 1983. Taurine in human lymphoblastoid cells: uptake and role in proliferation, Alan R Liss, Inc., New York, pp. 297–304.Google Scholar
  4. 4.
    Hunter, G.E., 1986, Adult ventricular myocytes isolated from CHF 146 and CHF 147 cardiomyopathic hamster, Can. J. Physiol. Pharm., 46:1503–1506.CrossRefGoogle Scholar
  5. 5.
    Jarvenpaa, A.L., Rassin, D.K., Raiha, N.C., and Gaull, G.E., 1982, Milk protein quantity and quality in the term infant, II. Effects on acidic and neutral amino acids, Pediatrics, 70:221–230.PubMedGoogle Scholar
  6. 6.
    Martensson, J. and Finnstrom, O., 1985, Metabolic effects of a human milk adapted formula on sulfur amino acid degradation in full-term infants., Early Hum. Dev., 11:333–339.PubMedCrossRefGoogle Scholar
  7. 7.
    Mattson, M.P., Dou, P., and Kater, S.B., 1988, Outgrowth-regulating actions of glutamate in isolated hippocampal pyramidal neurons, J. Neurosci, 8:2087–2100.PubMedGoogle Scholar
  8. 8.
    Rassin, D.K., Gaull, G.E., Jarvenpaa, A.L., and Raiha, N.C.R., 1983, Feeding the low-birth-weigth infant. II Effects of taurine and cholesterol supplementation on amino acids and cholesterol, Pediatrics, 71:179–186.PubMedGoogle Scholar
  9. 9.
    Sturman, J.A., 1983, Taurine in nutrition research, Prog. Clin. Biol Res., 125:281–295.PubMedGoogle Scholar
  10. 10.
    Sturman, J.A. and Gaull, G.E., 1975, Taurine in the brain and liver of the developing human and monkey, J. Neruochem, 25:831–835.CrossRefGoogle Scholar
  11. 11.
    Sturman, J.A. and Hayes, K.C., 1980, The biology of taurine in nutrition and development, Adv. Nutr. Res., 3:231–299.CrossRefGoogle Scholar

Copyright information

© Springer Science+Business Media New York 1998

Authors and Affiliations

  • Xue-Cun Chen
    • 1
  • Zhi-Ling Pan
    • 1
  • Dong-Sheng Liu
    • 1
  • Xiaobin Han
    • 2
  1. 1.Institute of Nutrition and Food HygieneCAPMBeijingChina
  2. 2.Department of PediatricsUniversity of TennesseeMemphisUSA

Personalised recommendations