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Taurine 3 pp 371-375 | Cite as

Taurine-Induced Potentiation is Partially Reversed by Low-Frequency Synaptic Stimlation

  • Nuria Del Olmo
  • Julián Bustamante
  • Rafael Martín del Río
  • José M. Solís
Part of the Advances in Experimental Medicine and Biology book series (AEMB, volume 442)

Abstract

Neuroinhibitory actions of taurine in the brain are well known to be mediated by the activation of GABAA receptors11. We have recently reported a new neuromodulatory taurine action in the hippocampus independent of this GABA receptor type8,9. The new taurine action consists of a long-lasting potentiation of synaptic transmission, that is induced when taurine is applied at a concentration of 5–10 mM over a 10–30 min period. Excitatory postsynaptic potentials (EPSP) increase during taurine application, remaining elevated long after taurine withdrawal (at least three hours). This new taurine action could have important relevance to brain function, since persistent changes in the synaptic strength are envisaged as the cellular substrate of learning and memory4. Taurine-induced potentiation, unlike long-term potentiation (LTP) induced by high frequency synaptic stimulation of afferent fibers, is independent of NMDA receptor activation8. Nevertheless, taurine-induced potentiation has some points in common with LTP, primarily because its induction requires a rise in intracellular calcium, and both potentiation phenomena occlude mutually (Del Olmo et al., in preparation).

Keywords

Synaptic Strength Excitatory Postsynaptic Potential Synaptic Efficacy Synaptic Potentiation Synaptic Stimulation 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

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Copyright information

© Springer Science+Business Media New York 1998

Authors and Affiliations

  • Nuria Del Olmo
    • 1
  • Julián Bustamante
    • 2
  • Rafael Martín del Río
    • 1
  • José M. Solís
    • 1
  1. 1.Servicio de Neurobiología Depto. de InvestigaciónHospital Ramón y CajalMadridSpain
  2. 2.Depto. de Fisiología Facultad de MedicinaUniversidad ComplutenseMadridSpain

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