Effects of NO-Generating Compounds on the Uptake and Release of Taurine in the Mouse Brain
Nitric oxide (NO) has been ascertained to play an important role in signal transduction in the central nervous system, functioning as a short-lived modulator and/or second messenger1,32. There is a functional link between NO and glutamatergic neurotransmission. NO is involved in synaptic plasticity, for example, in long-term potentiation, memory and learning, in the hippocampus4, which phenomena represent physiological effects of glutamate as a transmitter. Glutamate also participates in the development of ischemic brain injury, and therefore, NO is likely to be associated with mechanisms of neuronal damage4.
KeywordsNitric Oxide Nitric Oxide Sodium Nitroprusside Gaba Release Taurine Release
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