Dietary Taurine Supplementation Reduces Plasma and Liver Cholesterol and Triglyceride Levels in Rats Fed a High-Cholesterol or a Cholesterol-Free Diet
The effects of dietary taurine supplementation on plasma and hepatic lipid levels and phospholipid profiles were evaluated in rats fed a high-cholesterol or a cholesterol-free diet. Four groups of male rats were fed one of the following diets for 5 weeks: cholesterol-free diet (CFD); high cholesterol diet (HCD); high cholesterol, high taurine diet (HCHTD); or high taurine diet (HTD). Rats fed a HCHTD had significantly lower plasma levels of total cholesterol (32% reduction), LDL-cholesterol (37% reduction) and triglyceride (43% reduction) than rats fed a HCD alone. Plasma concentrations of total cholesterol, LDL-cholesterol and triglyceride were also significantly reduced in rats fed a HTD compared to rats fed a CFD. Taurine supplementation to the HCD significantly reduced hepatic cholesterol (50% decrease) and triglyceride (30% decrease) levels in rats. Taurine supplementation to the CFD also significantly reduced the hepatic triglyceride concentration (43% decrease) and elevated hepatic free fatty acid levels (77% increase) compared to rats fed only a CFD. These results suggest that dietary taurine supplementation is both hypocholesterolemic and hypotriglyceridemic in rats whose body cholesterol status is high or normal.
KeywordsBile Acid Hepatic Cholesterol Hepatic Triglyceride Body Weight Ratio Bile Acid Metabolism
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- 7.Cantafora, A., Yan, C.C., Sun, Y., and Masella, R., 1994, Effects of taurine on microsomal enzyme activities involved in liver lipid metabolism of wistar rats, in: “Taurine in Health and Disease”, Huxtable, R. and Michalk, D.V. eds., Plenum Press, New York, pp. 99–110.Google Scholar
- 8.Christie, W.W., 1982, The analysis of complex lipids, in: “Lipid Analysis,” Christie, W.W., ed., Pergamon Press, New York, pp. 115–121.Google Scholar
- 12.Gandhi, V.M., Cherian, K.M., and Mulky, M.J., 1992, Hypolipidemic action of taurine in rats, Ind. J. Expt. Biol., 30:413–417.Google Scholar
- 24.Tiedemann, F. and Gmelin, L., 1987, Einige neue bestandtheile der galle des fochsen., Ann. Physik Chem., 9:326–327.Google Scholar