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Taurine 3 pp 319-325 | Cite as

Dietary Taurine Supplementation Reduces Plasma and Liver Cholesterol and Triglyceride Levels in Rats Fed a High-Cholesterol or a Cholesterol-Free Diet

  • Taesun Park
  • Kyungshin Lee
Part of the Advances in Experimental Medicine and Biology book series (AEMB, volume 442)

Abstract

The effects of dietary taurine supplementation on plasma and hepatic lipid levels and phospholipid profiles were evaluated in rats fed a high-cholesterol or a cholesterol-free diet. Four groups of male rats were fed one of the following diets for 5 weeks: cholesterol-free diet (CFD); high cholesterol diet (HCD); high cholesterol, high taurine diet (HCHTD); or high taurine diet (HTD). Rats fed a HCHTD had significantly lower plasma levels of total cholesterol (32% reduction), LDL-cholesterol (37% reduction) and triglyceride (43% reduction) than rats fed a HCD alone. Plasma concentrations of total cholesterol, LDL-cholesterol and triglyceride were also significantly reduced in rats fed a HTD compared to rats fed a CFD. Taurine supplementation to the HCD significantly reduced hepatic cholesterol (50% decrease) and triglyceride (30% decrease) levels in rats. Taurine supplementation to the CFD also significantly reduced the hepatic triglyceride concentration (43% decrease) and elevated hepatic free fatty acid levels (77% increase) compared to rats fed only a CFD. These results suggest that dietary taurine supplementation is both hypocholesterolemic and hypotriglyceridemic in rats whose body cholesterol status is high or normal.

Keywords

Bile Acid Hepatic Cholesterol Hepatic Triglyceride Body Weight Ratio Bile Acid Metabolism 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

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Copyright information

© Springer Science+Business Media New York 1998

Authors and Affiliations

  • Taesun Park
    • 1
  • Kyungshin Lee
    • 1
  1. 1.Department of Food and NutritionYonsei UniversitySeoulKorea

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