Taurine 3 pp 299-307 | Cite as

The Effects of Taurine and Biogenetically Related Sulfur-Containing Compounds on the Metabolism of and Hypothermia by Ethanol in the Rat

  • Vasilios Theofanopoulos
  • Cesar A. Lau-Cam
Part of the Advances in Experimental Medicine and Biology book series (AEMB, volume 442)

Abstract

Two main metabolic pathways have been described for the biosynthesis of taurine in mammals: the cysteine sulfinic acid pathway, entailing the formation of cysteine sulfinic acid from cysteine, followed by conversion of cysteine sulfinic acid to hypotaurine; and the cysteamine pathway, where cysteine is sequentially metabolized to phosphopantothenyl cysteine, cysteamine and hypotaurine7,19. In turn, hypotaurine is enzymatically oxidized to taurine which, ultimately, is reported to undergo a very limited conversion to isethionic acid in certain organs3,20. An alternate minor pathway to taurine may occur through the intermediate formation of cysteic acid from cysteine sulfinic acid3,13,23.

Keywords

Cysteine Fructose Methionine Vinyl Thiol 

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References

  1. 1.
    Aragon, C.M.G. and Amit, Z., 1993, Taurine and ethanol-induced conditioned taste aversion, Pharmacol. Biochem. Behav., 44:263–266.PubMedCrossRefGoogle Scholar
  2. 2.
    Aragon, C.M.G., Trudeau, L.E., and Amit, Z., 1992, Effect of taurine on ethanol-induced changes in open-field locomotor activity, Psychopharmacology, 107:337–340.PubMedCrossRefGoogle Scholar
  3. 3.
    Awapara, J. and Wingo, W.J., 1953, On the mechanism of taurine formation from cysteine in the rat, J. Biol. Chem., 203:189–194.PubMedGoogle Scholar
  4. 4.
    Boggan, W.O., Medberry, C., and Hopkins, D.H., 1978, Effect of taurine on some pharmacological properties of ethanol, Pharmacol. Biochem. Behav., 9:469–472.PubMedCrossRefGoogle Scholar
  5. 5.
    Dolara, P., Marino, P., and Buffoni, F., 1973, Effect of 2-aminomethanesulphonic acid (taurine) and 2-hydroxyethane sulphonic acid (isethionic acid) on calcium transport by rat liver mitochondria, Biochem. Pharmacol., 22:2085–2094.PubMedCrossRefGoogle Scholar
  6. 6.
    Eriksson, C.J.P., Sippel, H.W., and Forsander, O.A., 1977, The determination of acetaldehyde in biological samples by headspace gas chromatography, Anal. Biochem., 80:116–124.PubMedCrossRefGoogle Scholar
  7. 7.
    Federici, G., Ricci, G., Santoro, L., Antonucci, A., and Cavallini, D., 1980, Cysteamine pathway of taurine biosynthesis, in: “Natural Sulfur Compounds”, Cavallini, D., Gaull, G.E., and Zappa, V., eds., Plenum Press, New York, pp. 187–193.CrossRefGoogle Scholar
  8. 8.
    Ferko, A.P., 1991, Cysteine sulfinic acid can enhance the central depressant effect of ethanol in mice, Pharmacol. Biochem. Behav., 39:653–657.PubMedCrossRefGoogle Scholar
  9. 9.
    Ferko, A.P., 1987, Ethanol-induced sleep time: interaction with taurine, Pharmacol. Biochem. Behav., 27:235–238.PubMedCrossRefGoogle Scholar
  10. 10.
    Harada, K., 1982, Effects of L-cysteine on alcohol metabolism — in vivo and in vitro study, Jpn. J. Alcoh. Stud. Drug Depend., 17:S65–S66.Google Scholar
  11. 11.
    Hirayama, C, Kishimoto, Y., Wakushima, T., and Murawaki, Y., 1983, Mechanism of the protective action of thiol compounds in ethanol-induced liver injury, Biochem. Pharmacol., 32:321–325.PubMedCrossRefGoogle Scholar
  12. 12.
    Iida, S. and Hikichi, M., 1976, Effect of taurine on ethanol-induced sleeping time in mice, J. Stud. Alcoh., 37:19–26.Google Scholar
  13. 13.
    Jacobsen, J.G. and Smith, L.H., Jr., 1963, Comparison of decarboxylation of cysteine sulphinic acid-1-14C and cysteic acid-l-14C by human, dog, and rat liver and brain, Nature, 200:575–577.PubMedCrossRefGoogle Scholar
  14. 14.
    Lau-Cam, C.A., Theofanopoulos, V., Thadikonda, K.P., and DeNicola, M., 1992, Effect of fructose on the hypothermic response to ethanol in the rat, Res. Commun. Subst. Abuse, 13:203–217.Google Scholar
  15. 15.
    Lau-Cam, C.A., Theofanopoulos, V., and Thadikonda, K.P., 1994, Antagonistic effect of ascorbate on ethanol-induced hypothermia in the rat, Res. Commun. Subst. Abuse, 15:33–50.Google Scholar
  16. 16.
    McBroom, M.J., Elkhawad, A.O., and Dlouha, H., 1986, Taurine and ethanol-induced sleeping time in mice: route and time course effects, Gen. Pharmacol., 17:97–100.PubMedCrossRefGoogle Scholar
  17. 17.
    Messiha, F.S., 1979, Taurine, analogues and ethanol elicited responses, Brain Res. Bull., 4:603–607.PubMedCrossRefGoogle Scholar
  18. 18.
    Messiha, F.S., 1987, Differential response of NADP-linked hepatic aldehyde dehydrogenase toward taurine: implication for behavioural effects of ethanol, J. Appl. Toxicol., 70:193–196.CrossRefGoogle Scholar
  19. 19.
    Pasantes-Morales, H., Chatagner, F., and Mandel, P., 1980, Synthesis of taurine in rat liver and brain in vivo, Neurochem. Res., 5:441–451.PubMedCrossRefGoogle Scholar
  20. 20.
    Peck, E.J., Jr. and Awapara, J., 1967, Formation of taurine and isethionic acid in rat brain, Biochim., Biophys. Acta, 141:499–506.CrossRefGoogle Scholar
  21. 21.
    Rachamin, G., Macdonald, J.A., Wahid, S., Clapp, J.J., Khanna, J.M., and Israel, Y., 1980, Modulation of alcohol dehydrogenase and ethanol metabolism by sex hormones in the spontaneously hypertensive rat, Biochem. J., 180:483–490.Google Scholar
  22. 22.
    Riley, V., 1960, Adaptation of orbital bleeding technique to rapid serial blood studies, Proc. Soc. Exp. Biol. Med., 104;751–754.PubMedCrossRefGoogle Scholar
  23. 23.
    Sturman, J.A. and Fellman, J.H., 1983, Methionine metabolism in the rat: accumulation of hypotaurine after partial hepatectomy, in: “Sulfur Amino Acids: Biochemical and Clinical Aspects”, Kuriyama, K., Huxtable, R.J., and Iwata, H., eds., Alan R. Liss, New York, pp. 435–447.Google Scholar
  24. 24.
    Theofanopoulos, V. and Lau-Cam, C.A., 1996, Modification of ethanol metabolism by taurine and its impact on ethanol-induced hypothermia in the rat, Pharm. Res. (Suppl.) 40:67P.Google Scholar
  25. 25.
    Vallee, B.L. and Hoch, F.L., 1955, Zinc, a component of yeast alcohol dehydrogenase Proc. Nat. Acad. Sci., 41:327–338.PubMedCrossRefGoogle Scholar
  26. 26.
    Vasiliou, V. and Marselos, M., 1989, Tissue distribution of inducible aldehyde dehydroxygenase activity in the rat after treatment with phenobarbital or methylcholanthrene, Pharmacol. Toxicol., 64:39–42.PubMedCrossRefGoogle Scholar
  27. 27.
    Wollenberger, A., Ristau, O., and Schoffa, G., 1960. A simple technic for extremely rapid freezing of large pieces of tissue, Pflueger Arch. Ges. Physiol., 270:399–412.PubMedCrossRefGoogle Scholar

Copyright information

© Springer Science+Business Media New York 1998

Authors and Affiliations

  • Vasilios Theofanopoulos
    • 1
  • Cesar A. Lau-Cam
    • 1
  1. 1.College of Pharmacy and Allied Health ProfessionsSt John’s UniversityJamaicaUSA

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