Taurine 3 pp 291-298 | Cite as

Taurine Can Ameliorate Inflammatory Bowel Disease in Rats

  • Miwon Son
  • Jun Il Ko
  • Won Bae Kim
  • Hee Kyoung Kang
  • Byong Kak Kim
Part of the Advances in Experimental Medicine and Biology book series (AEMB, volume 442)


We previously reported that the protective effect of taurine against indomethacin-induced gastric mucosal injury was due to its antioxidant effects which inhibited lipid peroxidation and neutrophil activation. In this sudy, we examined the effect of taurine on reducing the inflammatory parameters of trinitrobenzene sulfonic acid (TNBS)-induced inflammatory bowel disease (IBD) in rats. To induce IBD, rats were given ethanolic TNBS intracolonically. The rats then received 500 mg/kg/day of taurine per orally. The rats were sacrificed one week after IBD induction. Ulceration and inflammation of the distal colon with formation of granuloma in the vehicle-treated IBD rats after two days of administration of TNBS were observed. Treatment with 0.5 g/kg of taurine by the oral route ameliorated colonic damage and decreased the incidence of diarrhea and adhesions. Colon weight (an index of tissue edema) was markedly increased in the IBD rats after adminstration of TNBS, but was significantly lower after taurine treatment. Myeloperoxidase (MPO) activity in the vehicle-treated IBD rats was substantially increased compared with that of the control. The taurine-treated animals showed reduced MPO activity (35% lower) when compared with that of the vehicle-treated animals. Taurine treatment decreased basal and formyl-methionyl leucyl phenylalanine (FMLP) stimulated reactive oxygen generation in colonic tissue of the IBD rat compared with vehicle treatment after one week. These results suggest that administration of taurine reduced the inflammatory parameters in this rat model of IBD by increasing the defenses against oxidative insult.


Inflammatory Bowel Disease Colonic Damage Taurine Treatment Inflammatory Bowel Disease Induction Taurine Chloramine 
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Copyright information

© Springer Science+Business Media New York 1998

Authors and Affiliations

  • Miwon Son
    • 1
  • Jun Il Ko
    • 1
  • Won Bae Kim
    • 1
  • Hee Kyoung Kang
    • 2
  • Byong Kak Kim
    • 3
  1. 1.Research Laboratories of Dong-A Pharmaceutical Co., Ltd.Yongin-shi, Kyunggi-doKorea
  2. 2.Department of PharmacologySeoul National University College of MedicineChongno-gu, SeoulKorea
  3. 3.College of Pharmacy, Seoul National UniversityKwanak-gu, SeoulKorea

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