Hypotaurine Protection on Cell Damage by H2O2 and on Protein Oxidation by Cu++ and H2O2
The antioxidant activity of hypotaurine on cell structure has primarily been studied utilizing artificial liposomes and isolated lipoproteins18. Most studies with whole cells have utilized sperm cells to study the effect of oxidative stress on cellular function in the presence of varying concentrations of hypotaurine1,4,11,14,19. In this paper we will report experiments performed using two in vitro model systems.
KeywordsMelanoma Cell Neuroblastoma Cell Protein Oxidation Significant Protective Effect Culture Neuroblastoma Cell
Unable to display preview. Download preview PDF.
- 11.Huxtable R.J., 1992, Physiological actions of taurine, Physiol. Reviews, 72:101–163.Google Scholar
- 14.Meizel, S., Lui, C.W., Working, P.K., and Mrsny, R.J., 1980, Taurine and hypotaurine: their effects on motility, capacitation and the acrosome reaction of hamster sperm in vitro and their presence in sperm and reproductive tract fluids of several mammals, Dev. Growth Differ., 22:483–494.CrossRefGoogle Scholar
- 16.Pruitt, K.M., Kamau, D. N., Miller, K., Mansson-Rahemtulla, B., and Rahemtulla, F., 1990, Quantitative, Standardized Assays for Determining the Concentration of Bovine Lactoperoxidase, Human Salivary Peroxidase, and Human Myeloperoxidase, 191:278–286.Google Scholar
- 17.Ricci, G., Duprè, S., Federici, G., Spoto, G., Matarese, R.M., and Cavallini, D., 1978, Oxidation of hypotaurine to taurine by ultraviolet irradiation, Physiol. Chem. & Phys., 10:435–441.Google Scholar