Effects of Taurine in Precision-Cut Liver Slices Exposed to the Pyrrolizidine Alkaloid, Retrorsine
Pyrrolizidine alkaloids (PA) comprise a major group of toxins derived from plants. They are botanically and geographically widespread and cause many public health and economic problems5. PAs cause hepatomegaly, veno-occlusive disease of the liver, and cirrhosis7. The toxicity of PAs can also be expressed in other organ systems, including the heart, lung, and central nervous system.
KeywordsLiver Slice Pyrrolizidine Alkaloid Intracellular Potassium Concentration Cell Energy Status Cold Preservation Solution
Unable to display preview. Download preview PDF.
- 5.Huxtable, R. J., 1989, Human health implications of pyrrolizidine alkaloids and herbs containing them, in: “Toxicants of Plant Origin, Vol I: Alkaloids”,. Cheeke, P.R., ed., CRC Press, Boca Raton, Florida, pp. 41–86.Google Scholar
- 6.Lake, N., 1993, Loss of cardiac myofibrils: Mechanism of contractile deficits induced by taurine deficiency, Am. J. Physiol. Heart Circ. Physiol., 264:H1323–H1326.Google Scholar
- 8.Watanabe, A., Hobara, N., Kobayashi, M., and Nagashima, H., 1985, Effect of taurine on blood acetaldehyde elevation following alcohol ingestion, Res. Comm. Sub. Abuse, 6:247–250.Google Scholar