Development of a Marker of Estrogenic Exposure in Breast Cancer Patients
The effort to develop markers of exposure to endocrine disrupting chemicals (EDC) is a response to demands by the public and regulatory agencies for the evaluation of the role of these hormonal xenobiotics in human health (Sonnenschein et al., 1995). Exposure to EDC occurs mainly through diet but also in an occupational setting. For example, organochlorine pesticides and polychlorinated biphenyls enter the human organism via food and water but they also may accede to humans, mainly those professionally exposed, by inhalation and contact. Many of these organochlorine derivatives accumulate in fat tissues because of their solubility in lipids and inefficient metabolism. It is acknowledged that the environmental accumulation of organochlorines has been decreasing since 1970 in Europe and the USA but that human body burden has decreased at a slower rate (Furst et al., 1994).
KeywordsBreast Cancer High Performance Liquid Chromatography Breast Cancer Patient Organochlorine Pesticide Electron Capture Detector
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