Organochlorine Compounds and Xenoestrogens in Human Endometrium
Numerous in vitro-studies have demonstrated weak estrogenic effects of a large number of environmental chemicals (Jobling et al., 1995; Soto et al., 1994; Colborn and Clement, 1992). A major limitation of in vitro-testing is that it does not account for pharmacokinetic properties of the test compounds. Many xenoestrogens contain hydroxy groups or ester bonds which render them to rapid biotransformation and elimination. However, due to chronic intake buildung up of equilibrium concentrations of those compounds cannot be excluded. Therefore, human exposure data of reproductive tissues with environmental chemicals, e. g. xenoestrogens, are a prerequisite for prioritizing potential harzardous compounds for further risk assessment. In our study we have investigated tissue concentrations of organochlorines and xenoestrogens (e. g. DDT, PCB, HCB, HCH, endosulfane, alkylphenols, bisphenol A, phthalates and butylated hydroxyanisol) (Fig. 1) in human endometrium and in body fat.
KeywordsEstrogenic Activity Reproductive Tissue Estrogenic Effect Organochlorine Compound Human Endometrium
Unable to display preview. Download preview PDF.
- Colborn, T. and Clement, C., 1992, Chemically-induced alterations in sexual and functional development: The wildlife/human connection, Princeton Scientific Publishing, Princeton, NJ.Google Scholar