Analysis of Gene Regulation in Sertoli Cells by a Gene Trap Approach

  • Luis A. López-Fernández
  • Pascal Lopez
  • Fréderique Vidal
  • Fariba Ranc
  • François Cuzin
  • Minoo Rassoulzadegan
Part of the Advances in Experimental Medicine and Biology book series (AEMB, volume 444)


In mammals, the male gamete is the product of complex events, including meiosis, genetic recombination and spermiogenesis. Alterations in some of these regulatory events can affect fertility. The difficulty of reproducing in vitro the necessary requirements for the development of spermatogenesis has limited the progress of our knowledge of the molecular mechanisms which regulate spermatogenesis. Identification of spermatogenic regulatory genes will be useful to develop an in vitro system to test potential pharmacotoxicological agents.


Germ Cell Sertoli Cell Male Germ Cell Seminiferous Epithelium Myosin Heavy Chain Isoforms 
These keywords were added by machine and not by the authors.


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Copyright information

© Springer Science+Business Media New York 1998

Authors and Affiliations

  • Luis A. López-Fernández
    • 1
  • Pascal Lopez
    • 1
  • Fréderique Vidal
    • 1
  • Fariba Ranc
    • 1
  • François Cuzin
    • 1
  • Minoo Rassoulzadegan
    • 1
  1. 1.Unité 470 de l’Institut National de la Santé et de la Recherche Médicale, Faculté des SciencesUniversité de NiceNiceFrance

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