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Stimulants

  • Russell A. Barkley
  • George J. DuPaul
  • Daniel F. Connor

Abstract

The stimulant medications are the most commonly used psychotropic drugs employed with children, especially where inattentive, hyperactive, and/or impulsive behavior is sufficiently severe to impact adversely on school functioning or social adjustment. It has been estimated that 1.5 million children annually, 2.8% of the school-age population, may be using stimulants for behavior management.1 Historically, most of the individuals for whom stimulants were prescribed were children between 5 and 12 years of age. But, more recently, there has been a significant increase in the prescription of these medications for adolescents, particularly for those diagnosed as having attention-deficit hyperactivity disorder (ADHD).2

Keywords

Attention Deficit Hyperactivity Disorder Tourette Syndrome Stimulant Medication Attention Deficit Hyperactivity Disorder Symptom Acad Child Adolesc Psychiatry 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

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References

  1. 1.
    Safer DJ, Zito JM, Fine EM: Increased methylphenidate usage for attention deficit disorder in the 1990s. Pediatrics 98:1084–1088, 1996.PubMedGoogle Scholar
  2. 2.
    American Psychiatric Association: Diagnostic and Statistical Manual of Mental Disorders, 3 ed, revised. Washington DC, American Psychiatric Association, 1987.Google Scholar
  3. 3.
    Barkley RA: Attention Deficit Hyperactivity Disorder: A Handbook for Diagnosis and Treatment. New York, Guilford, 1990.Google Scholar
  4. 4.
    Lou HC, Henriksen L, Brunn P: Focal cerebral hypoperfusion in children with dysphasia and/or attention deficit disorder. Arch Neurol 41:825–829, 1984.PubMedCrossRefGoogle Scholar
  5. 5.
    Lou HC, Henriksen L, Bruhn P, et al: Striatal dysfunction in attention deficit and hyperkinetic disorder. Arch Neurol 46:48–52, 1989.PubMedCrossRefGoogle Scholar
  6. 6.
    Redman CA, Zametkin AJ: Ritalin and brain metabolism, in Greenhill LL, Osmon BB (eds): Ritalin: Theory and Patient Management. New York, Mary Ann Liebert, 1991, pp 301–309.Google Scholar
  7. 7.
    Gualtieri CT, Hicks RE, Mayo JP: Hyperactivity and homeostasis. J Am Acad Child Adolesc Psychiatry 22:382–384, 1983.CrossRefGoogle Scholar
  8. 8.
    Haenlein M, Caul WF: Attention deficit disorder with hyperactivity: A specific hypothesis of reward dysfunction. J Am Acad Child Adolesc Psychiatry 26:356–362, 1987.PubMedCrossRefGoogle Scholar
  9. 9.
    Diener RM: Toxicology of Ritalin, in Greenhill LL, Osmon BB (eds): Ritalin: Theory and Patient Management. New York, Mary Ann Liebert, 1991, pp 34–43.Google Scholar
  10. 10.
    Brown GL, Hunt RD, Ebert MH, et al: Plasma levels of d- amphetamine in hyperactive children. Psycho-pharmacology 62:133–140, 1979.CrossRefGoogle Scholar
  11. 11.
    Dulcan MK: Using psychostimulants to treat behavioral disorders of children and adolescents. J Child Adolesc Psychopharmacol 1:7–20, 1990.PubMedCrossRefGoogle Scholar
  12. 12.
    Wargin W, Patrick K, Kilts C, et al: Pharmacokinetics of methylphenidate in man, rat, and monkey. J Pharmacol Exp Ther 226:382–386, 1983.PubMedGoogle Scholar
  13. 13.
    Cantwell D, Carlson G: Stimulants, in Werry J (ed): Pediatric Psychopharmacology. New York, Brunner/ Mazel, 1978, pp 171–207.Google Scholar
  14. 14.
    Birmaher B, Greenhill LL, Cooper TB, Fried J, Maminski B: Sustained release methylphenidate: Pharmacokinetic studies in ADDH males. J Am Acad Child Adolesc Psychiatry 28:768–772, 1989.PubMedCrossRefGoogle Scholar
  15. 15.
    Pelham WE, Sturges J, Hoza J, et al: Sustained release and standard methylphenidate effects on cognitive and social behavior in children with attention deficit disorder. Pediatrics 4:491–501, 1987.Google Scholar
  16. 16.
    Pelham WE, Greenslade KE, Vodde-Hamilton M, et al: Relative efficacy of long-acting stimulants on children with attention deficit-hyperactivity disorder: A comparison of standard methylphenidate, sustained-release methylphenidate, sustained-release dextroamphetamine, and pemoline. Pediatrics 86:226–237, 1990.PubMedGoogle Scholar
  17. 17.
    Fitzpatrick PA, Klorman R, Brumaghim JT, Borgstedt AD: Effects of sustained-release and standard preparations of methylphenidate on attention deficit disorder. J Am Acad Child Adolesc Psychiatry 31:226–234, 1992.PubMedCrossRefGoogle Scholar
  18. 18.
    Patrick KS, Mueller RA, Gualtieri CT, et al: Pharmacokinetics and actions of methylphenidate, in Meltzer HY (ed): Psychopharmacology: The Third Generation of Progress. New York, Raven Press, 1987.Google Scholar
  19. 19.
    Sallee F, Stiller R, Perel J, et al: Oral pemoline kinetics in hyperactive children. Clin Pharmacol Ther 37:606–609, 1985.PubMedCrossRefGoogle Scholar
  20. 20.
    Pelham WE, Swanson JM, Furman MB, Schwindt H: Pemoline effects on children with ADHD: A time-response by dose-response analysis on classroom measures. J Am Acad Child Adolesc Psychiatry 34:1504–1513, 1995.PubMedCrossRefGoogle Scholar
  21. 21.
    Kupietz SS: Ritalin blood levels and their correlations with measures of learning, in Greenhill LL, Osmon BB (eds): Ritalin: Theory and Patient Management. New York, Mary Ann Liebert, 1991, pp 247–256.Google Scholar
  22. 22.
    Swanson JM: Measurement of serum concentrations and behavioral response in ADDH children to acute doses of methylphenidate, in LB Bloomingdale (ed): Attention Deficit Disorder: New Research in Attention, Treatment, and Psychopharmacology. New York, Pergamon Press, 1988.Google Scholar
  23. 23.
    Swanson J, Kinsbourne M, Roberts W, et al: Time-response analysis of the effect of medication on the learning ability of children referred for hyperactivity. Pediatrics 61:21–29, 1978.PubMedGoogle Scholar
  24. 24.
    Shaywitz SE, Shaywitz BA: Attention deficit disorder: Diagnosis and role of Ritalin in management, in Greenhill LL, Osmon BB (eds): Ritalin: Theory and Patient Management. New York, Mary Ann Liebert, 1991, pp 45–68.Google Scholar
  25. 25.
    Barkley RA: A review of stimulant drug research with hyperactive children. J Child Psychol Psychiatry 18:137–165, 1977.PubMedCrossRefGoogle Scholar
  26. 26.
    DuPaul GJ, Rapport MD: Does methylphenidate normalize the classroom performance of children with attention deficit disorder? J Am Acad Child Adolesc Psychiatry 32:190–198, 1993.PubMedCrossRefGoogle Scholar
  27. 27.
    Rapport MD, Denny C, DuPaul GJ, Gardner MJ: Attention deficit disorder and methylphenidate: Normalization rates, clinical effectiveness, and response prediction in 76 children. J Am Acad Child Adolesc Psychiatry 33:882–893, 1994.PubMedCrossRefGoogle Scholar
  28. 28.
    DuPaul GJ, Barkley RA, McMurray MD: Response of children with ADHD to methylphenidate: Interaction with internalizing symptoms. J Am Acad Child Adolesc Psychiatry 33:894–903, 1994.PubMedCrossRefGoogle Scholar
  29. 29.
    Pelham WE: Pharmacotherapy for children with attention-deficit hyperactivity disorder. School Psychol Rev 22:199–227, 1993.Google Scholar
  30. 30.
    Spencer T, Biederman J, Wilens T, Harding M, O’Donnell D, Griffin S: Pharmacotherapy of attention-deficit hyperactivity disorder across the life cycle. J Am Acad Child Adolesc Psychiatry 35:409–432, 1996.PubMedCrossRefGoogle Scholar
  31. 31.
    Swanson JM, McBurnett K, Christian DL, Wigal T: Stimulant medications and the treatment of children with ADHD, in Ollendick TH, Prinz RJ (eds): Advances in Clinical Child Psychology, New York, Plenum, 1995, vol 17, pp 265–322.CrossRefGoogle Scholar
  32. 32.
    Elia J, Rapoport JL: Ritalin versus dextroamphetamine in ADHD: Both should be tried, in Greenhill LL, Osmon BB (eds): Ritalin: Theory and Patient Management. New York, Mary Ann Liebert, 1991, pp 69–74.Google Scholar
  33. 33.
    Reeve E, Garfinkel B: Neuroendocrine and growth regulation: The role of sympathomimetic medication, in Greenhill LL, Osmon BB (eds): Ritalin: Theory and Patient Management. New York, Mary Ann Liebert, 1991, pp 289–300.Google Scholar
  34. 34.
    Klein RG, Mannuzza S: Hyperactive boys almost grown up: III. Methylphenidate effects on ultimate height. Arch Gen Psychiatry 45:1131–1134, 1988.PubMedCrossRefGoogle Scholar
  35. 35.
    Gittelman R, Landa B, Mattes JA, et al: Methylphenidate and growth in hyperactive children. Arch Gen Psychiatry 45:1127–1130, 1988.CrossRefGoogle Scholar
  36. 36.
    Kalikow KT, Blumencranz H: Severe weight loss induced by Adderall in a child with ADHD. J Child Adolesc Psychopharmacol 6:81–82.Google Scholar
  37. 37.
    Hastings JE, Barkley RA: A review of psychophysiological research with hyperactive children. J Abnorm Child Psychol 7:413–447, 1978.CrossRefGoogle Scholar
  38. 38.
    Rosenthal RH, Allen TW: An examination of attention, arousal, and learning dysfunctions of hyperkinetic children. Psychol Bull 85:689–715, 1978.PubMedCrossRefGoogle Scholar
  39. 39.
    Taylor EA: The Overactive Child. Philadelphia, LP Lippincott, 1986.Google Scholar
  40. 40.
    Kelly KL, Rapport MD, DuPaul GJ: Attention deficit disorder and methylphenidate: A multi-step analysis of dose response effects on children’s cardiovascular functioning. Int Clin Psychopharmacol 3:167–181,1988.PubMedCrossRefGoogle Scholar
  41. 41.
    Aman MG, Werry JS: The effects of methylphenidate and haloperidol on the heart rate and blood pressure of hyperactive children with special reference to time of action. Psychopharmacology 43:163–168, 1975.CrossRefGoogle Scholar
  42. 42.
    Safer DJ: Relative cardiovascular safety of psychostimulants used to treat attention-deficit hyperactivity disorder. J Child Adolesc Psychopharmacol 2:279–290, 1992.PubMedCrossRefGoogle Scholar
  43. 43.
    Knights RM, Viets A: Effects of pemoline on hyperactive boys. Pharmacol Biochem Behav 3:1107–1114, 1975.PubMedCrossRefGoogle Scholar
  44. 44.
    Brown RT, Sexson SB: Effects of methylphenidate on cardiovascular responses in attention deficit hyperactivity disordered adolescents. J Adolesc Health Care 10:179–183, 1989.PubMedCrossRefGoogle Scholar
  45. 45.
    Barkley RA, Jackson T Jr: Hyperkinesis, autonomic nervous system activity, and stimulant drug effects. J Child Psychol Psychiatry 18:347–357, 1977.PubMedCrossRefGoogle Scholar
  46. 46.
    Satterfield JH, Dawson ME: Electrodermal correlates of hyperactivity in children. Psychophysiology 8:191 – 197, 1971.PubMedCrossRefGoogle Scholar
  47. 47.
    Coons HW, Kloraian R, Borgstedt AD: Effects of methylphenidate on adolescents with a childhood history of attention deficit disorder: H. Information processing. J. Am Acad Child Adolesc Psychiatry 26:368–374, 1987.PubMedCrossRefGoogle Scholar
  48. 48.
    Peloquin LJ, Kloraian R: Effects of methylphenidate on normal children’s mood, event-related potentials, and performance in memory scanning and vigilance. J Abnorm Psychol 95:88–98, 1986.PubMedCrossRefGoogle Scholar
  49. 49.
    Zametkin A, Nordahl T, Gross M, et al: Brain metabolism in hyperactive adults with childhood onset. N Engl J Med 323:1361–1366, 1990.PubMedCrossRefGoogle Scholar
  50. 50.
    Bergman A, Winters L, Cornblatt B: Methylphenidate: Effects on sustained attention, in Greenhill LL, Osmon BB (eds): Ritalin: Theory and Patient Management. New York, Mary Ann Liebert, 1991, pp 223–232.Google Scholar
  51. 51.
    Barkley RA, Cunningham CE: The effects of methylphenidate on the mother-child interactions of hyperactive children. Arch Gen Psychiatry 36:201–208, 1979.PubMedCrossRefGoogle Scholar
  52. 52.
    Swanson J, Kinsbourne M: The cognitive effects of stimulant drugs on hyperactive children, in Hale GA, Lewis M (eds): Attention and Cognitive Development. New York, Plenum, 1978, pp 249–274.Google Scholar
  53. 53.
    Elia J, Borcherding BG, Rapoport JL, Keysor CS: Methylphenidate and dextroamphetamine treatments of hyperactivity: Are there true nonresponders? Psychiatry Res 36:141–155, 1991.PubMedCrossRefGoogle Scholar
  54. 54.
    Milich R, Carlson CL, Pelham WE, Licht BG: Effects of methylphenidate on the persistence of ADHD boys following failure experiences. J Abnorm Child Psychol 19:519–536, 1991.PubMedCrossRefGoogle Scholar
  55. 55.
    Abikoff H, Gittelman R: Does behavior therapy normalize the classroom behavior of hyperactive children? Arch Gen Psychiatry 41:449–454, 1984.PubMedCrossRefGoogle Scholar
  56. 56.
    DuPaul GJ, Rapport M: Attention deficit disorder: Does methylphenidate normalize classroom functioning? Paper presented at the American Psychological Association, August, San Francisco, Calif, 1991.Google Scholar
  57. 57.
    Pelham WE, Milich R: Individual differences in response to Ritalin in class work and social behavior, in Greenhill LL, Osmon BB (eds): Ritalin: Theory and Patient Management. New York, Mary Ann Liebert, 1991, pp 203–221.Google Scholar
  58. 58.
    Pelham WE, McBurnet K, Harper GW, Milich R, et al: Methylphenidate and baseball playing in ADHD children: Who’s on first? J Consult Clin Psychol 58:130–133, 1990.PubMedCrossRefGoogle Scholar
  59. 59.
    Barkley RA, Fischer M, Newby R, et al: Development of a multi-method clinical protocol for assessing stimulant drug responses in ADHD children. J Clin Child Psychol 17:14–24, 1988.CrossRefGoogle Scholar
  60. 60.
    Hinshaw SP: Stimulant medication and the treatment of aggression in children with attentional deficits. J Clin Child Psychol 20:301–312, 1991.CrossRefGoogle Scholar
  61. 61.
    Rapport MD, DuPaul GJ, Stoner G, et al: Comparing classroom and clinic measures of attention deficit disorder: Differential, idiosyncratic, and dose-response effects of methylphenidate. J Consult Clin Psychol 54:334–341, 1986.PubMedCrossRefGoogle Scholar
  62. 62.
    Rapport MD, Kelly KL: Psychostimulant effects on learning and cognitive function in children with attention deficit hyperactivity disorder: Findings and implications, in Matson JL (ed): Hyperactivity in Children: A Handbook. New York, Pergamon, 1991.Google Scholar
  63. 63.
    Hinshaw SP, Henker B, Whalen CK, Erhardt D, Dunnington RE: Aggressive, prosocial, and nonsocial behavior in hyperactive boys: Dose effects of methylphenidate in naturalistic settings. J Consult Clin Psychol 57:636–643, 1989.PubMedCrossRefGoogle Scholar
  64. 64.
    Murphy DA, Pelham WE, Lang AR: Aggression in boys with attention deficit-hyperactivity disorder: Methylphenidate effects on naturalistically observed aggression, response to provocation, and social information processing. J Abnorm Child Psychol 20:451–465, 1992.PubMedCrossRefGoogle Scholar
  65. 65.
    Shah MR, Seese LM, Abikoff H, Klein RG: Pemoline for children and adolescents with conduct disorder: A pilot investigation. J Child Adolesc Psychopharmacol 4:255–261, 1994.CrossRefGoogle Scholar
  66. 66.
    Hinshaw SP, Heller T, McHale JP: Covert antisocial behavior in boys with attention-deficit hyperactivity disorder: External validation and effects of methylphenidate. J Consult Clin Psychol 60:274–281, 1992.PubMedCrossRefGoogle Scholar
  67. 67.
    Rapoport JL, Buchsbaum MS, Zahn TP, et al: Dextroamphetamine: Cognitive and behavioral effects in normal prepubertal boys. Science 199:560–563, 1978.PubMedCrossRefGoogle Scholar
  68. 68.
    Solanto MV: Dosage effects of Ritalin on cognition, in Greenhill LL, Osmon BB (eds): Ritalin: Theory and Patient Management. New York, Mary Ann Liebert, 1991, pp 233–246.Google Scholar
  69. 69.
    Douglas VI, Barr RG, O’Neill ME, et al: Dosage effects and individual responsivity to methylphenidate in attention deficit disorder. J Child Psychol Psychiatry 29:453–475, 1988.PubMedCrossRefGoogle Scholar
  70. 70.
    Swanson JM: Paired-associate learning in the assessment of ADD-H children, in Bloomingdale LM, Swanson J (eds): Attention Deficit Disorder: Current Concepts and Emerging Trends in Attentional and Behavioral Disorders of Childhood. New York, Pergamon Press, 1989, pp 87–123.Google Scholar
  71. 71.
    Vyse SA, Rapport MD: The effects of methylphenidate on learning in children with ADDH: The stimulus-equivalence paradigm. J Consult Clin Psychol 57:425–435, 1989.PubMedCrossRefGoogle Scholar
  72. 72.
    Sergeant J, van der Meere JJ: Ritalin effects and information processing in hyperactivity, in Greenhill LL, Osmon BB (eds): Ritalin: Theory and Patient Management. New York, Mary Ann Liebert, 1991, pp 1–13.Google Scholar
  73. 73.
    Swanson JM: What do psychopharmacological studies tell us about information processing deficits in ADDH?, in Bloomingdale LM, Sergeant J (eds): Attention Deficit Disorder: Criteria, Cognition, Intervention. New York, Pergamon Press, 1988, pp 97–116.Google Scholar
  74. 74.
    Werry J: Pediatric Psychopharmacology. New York, Brunner/Mazel, 1978.Google Scholar
  75. 75.
    Becker-Mattes A, Mattes JA, Abikoff H, et al: State-dependent learning in hyperactive children receiving methylphenidate. Am J Psychiatry 142:455–459, 1985.PubMedGoogle Scholar
  76. 76.
    Stephens RS, Pelham WE, Skinner R: State-dependent and main effects of methylphenidate and pemoline on paired-associate learning and spelling in hyperactive children. J Consult Clin Psychol 52:104–113, 1984.PubMedCrossRefGoogle Scholar
  77. 77.
    Barkley RA, Cunningham CE: Do stimulant drugs improve the academic performance of hyperkinetic children? A review of outcome research. Clin Pediatrics 17:85–92, 1978.CrossRefGoogle Scholar
  78. 78.
    Gittelman R, Klein DF, Feingold I: Children with reading disorders — II: Effects of methylphenidate in combination with reading remediation. J Child Psychol Psychiatry 24:193–212, 1983.PubMedCrossRefGoogle Scholar
  79. 79.
    Weiss G, Hechtman L: Hyperactive Children Grown Up. New York, Guilford Press, 1986.Google Scholar
  80. 80.
    Barkley RA, Karlsson J, Pollard S, et al: Developmental changes in the mother-child interactions of hyperactive boys: Effects of two doses of Ritalin. J Child Psychol Psychiatry 26:705–715, 1985.PubMedCrossRefGoogle Scholar
  81. 81.
    Humphries T, Kinsbourne M, Swanson J: Stimulant effects on cooperation and social interaction between hyperactive children and their mothers. J Child Psychol Psychiatry 19:13–22, 1978.PubMedCrossRefGoogle Scholar
  82. 82.
    Barkley RA: Hyperactive girls and boys: Stimulant drug effects on mother-child interactions. J Child Psychol Psychiatry Allied Discip 30:379–390, 1989.CrossRefGoogle Scholar
  83. 83.
    Pelham WE, Walker JL, Sturges J, Hoza J: Comparative effects of methylphenidate on ADD girls and ADD boys. J Am Acad Child Adolesc Psychiatry28:773–776, 1989.PubMedCrossRefGoogle Scholar
  84. 84.
    Whalen CK, Henker D, Dotemoto S: Methylphenidate and hyperactivity: Effects on teacher behaviors. Science 208:1280–1282, 1980.PubMedCrossRefGoogle Scholar
  85. 85.
    Cunningham CE, Siegel LS, Offord DR: A developmental dose response analysis of the effects of methylphenidate on the peer interactions of attention deficit disordered boys. J Child Psychol Psychiatry 26:955–971, 1985.PubMedCrossRefGoogle Scholar
  86. 86.
    Whalen CK, Henker B, Collins BE, et al: Peer interaction in structured communication task: Comparisons of normal and hyperactive boys and of methylphenidate (Ritalin) and placebo effects. Child Dev 50:388–401, 1979.PubMedGoogle Scholar
  87. 87.
    Mino Y, Ohara H: Methylphenidate and interpersonal relationships of children with attention deficit hyperactivity disorder. Jpn J Psychiatry Neurol 45:45–51, 1991.PubMedGoogle Scholar
  88. 88.
    Granger DA, Whalen CK, Henker B: Perceptions of methylphenidate effects on hyperactive children’s peer interactions. J Abnorm Child Psychol 21:535–549, 1993.PubMedCrossRefGoogle Scholar
  89. 89.
    Whalen CK, Henker B, Hinshaw SP, et al: Messages of medication: Effects of actual versus informed medication status on hyperactive boys’ expectancies and self-evaluations. J Consult Clin Psychol 59:602–606, 1991.PubMedCrossRefGoogle Scholar
  90. 90.
    Iaolongo NS, Lopez, M, Horn WF, et al: Effects of psychostimulant medication on self-perceptions of competence, control, and mood in children with attention deficit hyperactivity disorder. J Clin Child Psychol 23:161–173, 1994.CrossRefGoogle Scholar
  91. 91.
    Pelham WE, Murphy DA, Vannatta K, Milich R, et al: Methylphenidate and attributions in boys with attention-deficit hyperactivity disorder. J Consult Clin Psychol 60:282–292, 1992.PubMedCrossRefGoogle Scholar
  92. 92.
    Carlson CL, Pelham WE, Milich R, Hoza B: ADHD boys’ performance and attributions following success and failure: Drug effects and individual differences. Cognit Ther Res 17:269–287, 1993.CrossRefGoogle Scholar
  93. 93.
    Sprague R, Sleator E: Drugs and dosages: Implications for learning disabilities, in Knights RM, Bakker DJ (eds): The Neuropsychology of Learning Disorders, Baltimore, Md, University Park Press, 1976, pp 351–366.Google Scholar
  94. 94.
    Sprague R, Sleator E: Methylphenidate in hyperkinetic children: Differences in dose effects on learning and social behavior. Science 198:1274–1276, 1977.PubMedCrossRefGoogle Scholar
  95. 95.
    Douglas VI, Barr RD, Desilets J, Sherman E: Do high doses of stimulants impair flexible thinking in attention-deficit hyperactivity disorder? J Am Acad Child Adolesc Psychiatry 34:877–885, 1995.PubMedCrossRefGoogle Scholar
  96. 96.
    Kaufman RE, Smith-Wright D, Reese CA, Simpson R, Jones F: Medication compliance in hyperactive children. Pediatr Pharmacol 1:231–237, 1981.Google Scholar
  97. 97.
    Pelham WE: The effects of stimulant drugs on learning and achievement in hyperactive and learning disabled children, in Torgesen JK, Wong B (eds): Psychological and Educational Perspectives on Learning Disabilities. New York, Academic Press, 1985, pp 259–295.Google Scholar
  98. 98.
    Schachar R, Tannock R: Childhood hyperactivity and psychostimulants: A review of extended treatment studies. J Child Adolesc Psychopharmacol 3:81–97, 1993.PubMedCrossRefGoogle Scholar
  99. 99.
    DuPaul GJ, Barkley RA: Medication therapy, in Barkley RA (ed): Attention Deficit Hyperactivity Disorder: A Handbook for Diagnosis and Treatment. New York, Guilford Press, 1990, pp 573–612.Google Scholar
  100. 100.
    Aman MG, Turbott SH: Prediction of clinical response in children taking methylphenidate. J Autism Dev Disord 21:211–227, 1991.PubMedCrossRefGoogle Scholar
  101. 101.
    Barkley RA: Predicting the response of hyperactive children to stimulant drugs: A review. J Abnorm Child Psychol 4:327–348, 1976.PubMedCrossRefGoogle Scholar
  102. 102.
    Taylor EA: Drug response and diagnostic validation, in Rutter M (ed): Developmental Neuropsychiatry. New York, Guilford Press, 1983, pp 348–368.Google Scholar
  103. 103.
    Rapport MD, DuPaul GJ, Smith NF: Rate-dependency and hyperactivity: Methylphenidate effects on operant responding. Pharmacol Biochem Behav 23:77–83, 1985.PubMedCrossRefGoogle Scholar
  104. 104.
    Barkley RA: Hyperactive Children: A Handbook for Diagnosis and Treatment. New York, Guilford Press, 1981.Google Scholar
  105. 105.
    Pliszka SR: Effect of anxiety on cognition, behavior, and stimulant response in ADHD. J. Am Acad Child Adolesc Psychiatry 28:882–887, 1989.PubMedCrossRefGoogle Scholar
  106. 106.
    Voelker S, Lachar D, Gdowski C: The Personality Inventory for Children and response to methylphenidate: Preliminary evidence for predictive validity. J Pediatr Psychol 8:161–169, 1983.PubMedCrossRefGoogle Scholar
  107. 107.
    Barkley RA, DuPaul JG: Psychostimulant response of children with ADHD: Interaction with internalizing symptoms. Paper presented at the American Psychological Association, August, San Francisco, Calif, 1991.Google Scholar
  108. 108.
    Aman MG: Stimulant drugs in developmental disabilities revisited. J Dev Phys Disabil, 8:347–365, 1996.CrossRefGoogle Scholar
  109. 109.
    Aman MG, Kern RA, Osborne P, et al: Fenfluramine and methylphenidate in children with mental retardation and borderline IQ: Clinical effects. Am J Ment Retard, in press.Google Scholar
  110. 110.
    Handen BL, Breaux AM, Janosky J, et al: Effects and noneffects of methylphenidate in children with mental retardation and ADHD. J Am Acad Child Adolesc Psychiatry 31:455–461, 1992.PubMedCrossRefGoogle Scholar
  111. 111.
    Handen BL, Janosky J, McAuliffe S, et al: Prediction of response to methylphenidate among children with ADHD and mental retardation. J Am Acad Child Adolesc Psychiatry 33:1185–1193, 1994.PubMedCrossRefGoogle Scholar
  112. 112.
    Barkley RA, McMurray MB, Edelbrock CS, et al: The side effects of Ritalin: A systematic placebo controlled evaluation of two doses. Pediatrics 86:184–192, 1990.PubMedGoogle Scholar
  113. 113.
    Fine S, Johnston C: Drug and placebo side effects in methylphenidate-placebo trial for attention deficit hyperactivity disorder. Child Psychiatry Hum Dev 24:25–30, 1993.PubMedCrossRefGoogle Scholar
  114. 114.
    Ahmann PA, Waltonen SJ, Olson KA, et al: Placebo-controlled evaluation of Ritalin side effects. Pediatrics 91:1101–1106, 1993.PubMedGoogle Scholar
  115. 115.
    Werry J, Sprague R: Methylphenidate in children: Effect of dosage. Aust N ZJ Psychiatry 8:9–19, 1974.CrossRefGoogle Scholar
  116. 116.
    Barkley RA: Tic disorders and Gilles de la Tourette syndrome, in Mash E, Terdal L (eds): Behavioral Assessment of Childhood Disorders, ed 2, New York, Guilford Press, 1988.Google Scholar
  117. 117.
    Bremness AB, Sverd J: Methylphenidate-induced Tourette syndrome: Case report. Am J Psychiatry 136:1334–1335, 1979.PubMedGoogle Scholar
  118. 118.
    Case ED, McAndrew JB: Dexedrine dyskinesia: An unusual iatrogenic tic. Clin Pediatr 13:69–70, 1974.CrossRefGoogle Scholar
  119. 119.
    Golden GS: Gilles de la Tourette’s syndrome following methylphenidate administration. Dev Med Child Neurol 16:76–78, 1974.PubMedCrossRefGoogle Scholar
  120. 120.
    Lowe TL, Cohen DJ, Detlor J, et al: Stimulant medications precipitate Tourette’s syndrome. JAMA 247:1729–1731, 1982.PubMedCrossRefGoogle Scholar
  121. 121.
    Mitchel E, Matthews KL: Gilles de la Tourette’s disorder associated with pemoline. Am J Psychiat 137:1618–1619, 1980.Google Scholar
  122. 122.
    Pollack MA, Cohen NL, Friedhoff AJ: Gilles de la Tourette’s syndrome: Familial occurrence and precipitation by methylphenidate therapy. Arch Neurol 34:630–632, 1977.PubMedCrossRefGoogle Scholar
  123. 123.
    Weiner WJ, Nausieda PA, Klawans HL: Methylphenidate-induced chorea: Case report and pharmacologic implications. Neurology 28:1041–1044, 1978.PubMedCrossRefGoogle Scholar
  124. 124.
    Caine ED, Ludlow CL, Polinsky RJ, et al: Provocative drug testing in Tourette’s syndrome: d- and 1-amphetamine and haloperidol. J Am Acad Child Psychiatry 23:147–152, 1984.PubMedCrossRefGoogle Scholar
  125. 125.
    Erenberg G, Cruse RP, Rothner AD: The effect of stimulant drugs on Tourette syndrome. Neurology 34:84, 1984.Google Scholar
  126. 126.
    Fras I, Karlavage J: The use of methylphenidate and imipramine in Gilles de la Tourette’s disease in children. Am J Psychiatry 134:195–197, 1977.PubMedGoogle Scholar
  127. 127.
    Denckla MB, Bemporad JR, MacKay MC: Tics following methylphenidate administration. JAMA 235:1349–1351, 1976.PubMedCrossRefGoogle Scholar
  128. 128.
    Golden GS: The use of stimulants in the treatment of Tourette’s syndrome, in Cohen DJ, Bruun RD, Leckman JF (eds): Tourette’s Syndrome & Tic Disorders: Clinical Understanding and Treatment. New York, John Wiley & Sons, 1988.Google Scholar
  129. 129.
    Gadow KD, Nolan EE, Sverd J: Methylphenidate in hyperactive boys with comorbid tic disorder: II. Short-term behavioral effects in school settings. J Am Acad Child Adolesc Psychiatry 31:462–471, 1992.PubMedCrossRefGoogle Scholar
  130. 130.
    Gadow KD, Sverd J, Sprafkin J, Nolan EE, Ezor SN: Efficacy of methylphenidate for attention-deficit hyperactivity disorder in children with tic disorder. Arch Gen Psychiatry 52:444–455, 1995.PubMedCrossRefGoogle Scholar
  131. 131.
    Johnston C, Pelham WE, Hoza J, et al: Psychostimulant rebound in attention deficit disordered boys. J Am Acad Child Adolesc Psychiatry 27:806–810, 1988.PubMedCrossRefGoogle Scholar
  132. 132.
    Dyme IZ, Sahakian BJ, Golinko B, et al: Perseveration induced by methylphenidate in children: Preliminary findings. Prog Neuro-psychopharmacol Biol Psychiatry 6:269–273, 1982.CrossRefGoogle Scholar
  133. 133.
    Solanto MV, Wender EK: Does methylphenidate constrict cognitive functioning? J. Am Acad Child Adolesc Psychiatry 28:897–902, 1989.PubMedCrossRefGoogle Scholar
  134. 134.
    Fiedler N, Ullman DG: The effects of stimulant drugs on curiousity behaviors of hyperactive boys. J Abnorm Child Psychol 11:193–206, 1983.PubMedCrossRefGoogle Scholar
  135. 135.
    Hinshaw SP, Buhrmester D, Heller T: Anger control in response to verbal provocation: Effects of stimulant medication for boys with ADHD. J Abnorm Child Psychol 17:393–407, 1989.PubMedCrossRefGoogle Scholar
  136. 136.
    Conners CK, Taylor E: Pemoline, methylphenidate, and placebo in children with minimal brain dysfunction. Arch Gen Psychiatry 37:922–932, 1980.PubMedCrossRefGoogle Scholar
  137. 137.
    Sallee FR, Stiller RL, Perel JM, et al: Pemoline-induced abnormal involuntary movements. J Clin Psycho-pharmacol 9:125–129, 1989.CrossRefGoogle Scholar
  138. 138.
    Safer DJ, Allen RP, Barr E: Depression of growth in hyperactive children on stimulant drugs. N Engl J Med 287:217–220, 1972.PubMedCrossRefGoogle Scholar
  139. 139.
    Safer RP, Allen DJ: Factors influencing the suppressant effects of two stimulant drugs on the growth of hyperactive children. Pediatrics 51:660–667, 1973.PubMedGoogle Scholar
  140. 140.
    Mattes JA, Gittelman R: Growth of hyperactive children on maintenance regimen of methylphenidate. Arch Gen Psychiatry 40:317–321, 1983.PubMedCrossRefGoogle Scholar
  141. 141.
    Spencer TJ, Biederman J, Harding M, O’Donnell D, Faraone SV, Wilens TE: Growth deficits in ADHD children revisited: Evidence for disorder-associated growth delays? J Am Acad Child Adolesc Psychiatry 35:1460–1469, 1996.PubMedCrossRefGoogle Scholar
  142. 142.
    Zeiner P: Body growth and cardiovascular function after extended (1.75 years) treatment with methylphenidate in boys with attention-deficit hyperactivity disorder. J Child Adolesc Psychopharmacol 5:129–138, 1995.CrossRefGoogle Scholar
  143. 143.
    Barkley RA, DuPaul GJ, McMurray MB: Attention deficit disorder with and without hyperactivity: Clinical response to three dose levels of methylphenidate. Pediatrics 87:519–531, 1991.PubMedGoogle Scholar
  144. 144.
    McBurnett K, Lahey BB, Swanson JM: Ritalin treatment in attention deficit disorder without hyperactivity, in Greenhill LL, Osmon BB (eds): Ritalin: Theory and Patient Management. New York, Mary Ann Liebert, 1991, pp 257–265.Google Scholar
  145. 145.
    Aman MG: Stimulant drug effects in developmental disorders and hyperactivity: Toward a resolution of disparate findings. J Autism Dev Disord 12:385–398, 1982.PubMedCrossRefGoogle Scholar
  146. 146.
    Aman MG, Marks RE, Turbott SH, et al: Clinical effects of methylphenidate and thioridazine in intellectually subaverage children. J. Am Acad Child Adolesc Psychiatry 30:246–256, 1991.CrossRefGoogle Scholar
  147. 147.
    Handen BL, Feldman H, Gosling A, et al: Adverse side effects of methylphenidate among mentally retarded children with ADHD. J. Am Acad Child Adolesc Psychiatry 30:241–245, 1991.PubMedCrossRefGoogle Scholar
  148. 148.
    Spencer T, Wilens T, Biederman J, Faraone SV, Ablon S, Lapey K: A double-blind, crossover comparison of methylphenidate and placebo in adults with childhood-onset attention deficit hyperactivity disorder. Arch Gen Psychiatry 52:434–443.Google Scholar
  149. 149.
    Crumrine PK, Feldman HM, Teodori J, et al: The use of methylphenidate in children with seizures and attention deficit disorder. Paper presented at the Child Neurology Society, October 1987.Google Scholar
  150. 150.
    McBridge MC, Wang DD, Torres CF: Methylphenidate in therapeutic doses does not lower seizure threshold. Ann Neurol 20;428, 1986.Google Scholar
  151. 151.
    Cohen D, Bruun RD, Leckman JF: Tourette Syndrome and Tic Disorders. New York, John Wiley & Sons, 1987.Google Scholar
  152. 152.
    Demb HB: Use of Ritalin in the treatment of children with mental retardation, in Greenhill LL, Osmon BB (eds): Ritalin: Theory and Patient Management. New York, Mary Ann Liebert, 1991, pp 155–170.Google Scholar
  153. 153.
    Gualtieri CT: Psychostimulants in traumatic brain injury, in Greenhill LL, Osmon BB (eds): Ritalin: Theory and Patient Management. New York, Mary Ann Liebert, 1991, pp 171–176.Google Scholar
  154. 154.
    Fernandez F: Ritalin in HIV dementia, in Greenhill LL, Osmon BB (eds): Ritalin: Theory and Patient Management. New York, Mary Ann Liebert, 1991, pp 177–186.Google Scholar
  155. 155.
    Brown RT, Jaffe SL, Silverstein J, et al: Methylphenidate and adolescents hospitalized with conduct disorder: Dose effects on classroom behavior, academic performance, and impulsivity. J Clin Child Psychol 20: 282–292, 1991.CrossRefGoogle Scholar
  156. 156.
    Donnelly M, Rapoport JL: Attention deficit disorders, in Wiener JM (ed): Diagnosis and Psychopharmacology of Childhood and Adolescent Disorders. New York, John Wiley & Sons, 1985, pp 178–198.Google Scholar
  157. 157.
    Greenhill LL: Methylphenidate in the clinical office practice of child psychiatry, in Greenhill LL, Osmon BB (eds): Ritalin: Theory and Patient Management. New York, Mary Ann Liebert, 1991, pp 97–118.Google Scholar
  158. 158.
    Barkley RA: The effects of methylphenidate on the interactions of preschool ADHD children with their mothers. J. Am Acad Child Adolesc Psychiatry 27:336–341, 1988.PubMedCrossRefGoogle Scholar
  159. 159.
    Pelham WE, Vodde-Hamilton M, Murphy DA, et al: The effects of methylphenidate on ADHD adolescents in recreational, peer group, and classroom settings. J Clin Child Psychol 20:293–300, 1990.CrossRefGoogle Scholar
  160. 160.
    Stein MA, Blondis TA, Schnitzler ER, et al: Methylphenidate dosing: b.i.d. versus t.i.d. Pediatrics, 98:748–756, 1996.PubMedGoogle Scholar
  161. 161.
    Kent JD, Blader JC, Koplewicz HS, et al: Effects of late-afternoon methylphenidate administration on behavior and sleep in attention-deficit hyperactivity disorder. Pediatrics 96:320–325, 1995.PubMedGoogle Scholar
  162. 162.
    Chan YM, Swanson JM, Soldin SS, et al: Methylphenidate hydrochloride given with or before breakfast: II. Effects on plasma concentrations of methylphenidate and ritalinic acid. Pediatrics 72:56–59, 1983PubMedGoogle Scholar
  163. 163.
    Gadow KD, Nolan EE, Paolicelli LM, et al: A procedure for assessing the effects of methylphenidate on hyperactive children in public school settings. J Clin Child Psychol 20:268–276, 1991.CrossRefGoogle Scholar
  164. 164.
    Grob CS, Coyle JT: Suspected adverse methylphenidate- imipramine interactions in children. J Dev Behav Pediatr 7:265, 1986.PubMedCrossRefGoogle Scholar
  165. 165.
    Rapport MD, Carlson GA, Kelly KL, Pataki C: Methylphenidate and desipramine in hospitalized children: I. Separate and combined effects on cognitive function. J Am Acad Child Adolesc Psychiatry 32:333–342, 1993.PubMedCrossRefGoogle Scholar
  166. 166.
    Pataki C, Carlson G, Kelly K, Rapport M, Biancaniello T: Side effects of methylphenidate and desipramine alone and in combination in children. Am J Psychiatry 32: 1065–1072, 1993.Google Scholar
  167. 167.
    Gammon BD, Brown TE: Fluoxetine and methylphenidate in combination for treatment of attention deficit disorder and comorbid depressive disorder. J Child Adolesc Psychopharmacol 3:1–10, 1993.PubMedCrossRefGoogle Scholar
  168. 168.
    Gunning B: A controlled trial of Clonidine in hyperkinetic children. Thesis, Department of Child and Adolescent Psychiatry, Academic Hospital Rotterdam, Sophia Children’s Hospital Rotterdam, The Netherlands, 1992.Google Scholar
  169. 169.
    Popper C: Combining methylphenidate and Clonidine: Pharmacologic questions and new reports about sudden death. J Child Adolesc Psychopharmacol 5:157–166, 1995.CrossRefGoogle Scholar
  170. 170.
    Swanson JM, Flockhart D, Udrea D, Cantwell D, Connor D, Williams L: Clonidine in the treatment of ADHD: Questions about safety and efficacy. J Child Adolesc Psychopharmacol 5:301–304, 1996.CrossRefGoogle Scholar

Copyright information

© Springer Science+Business Media New York 1999

Authors and Affiliations

  • Russell A. Barkley
    • 1
  • George J. DuPaul
    • 2
  • Daniel F. Connor
    • 1
  1. 1.Department of PsychiatryUniversity of Massachusetts Medical CenterWorcesterUSA
  2. 2.Department of School PsychologyLehigh UniversityBethlehemUSA

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